doi: 10.1038/284017a0.
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
- PMID: 6101906
- DOI: 10.1038/284017a0
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The role of hormone receptors and GTP-regulatory proteins in membrane transduction
Nature.
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Abstract
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.
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