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. 1984 Nov;3(11):2593-8.
doi: 10.1002/j.1460-2075.1984.tb02179.x.

Encephalomyocarditis virus RNA synthesis in vitro is protein-primed

A B Vartapetian, E V Koonin, V I Agol, A A Bogdanov

Encephalomyocarditis virus RNA synthesis in vitro is protein-primed

A B Vartapetian et al. EMBO J. 1984 Nov.

Abstract

A crude membrane-bound replication complex isolated from encephalomyocarditis virus-infected cells is able to initiate the synthesis of viral RNA. Both the formation of the primer, VPg-pU, and its utilization for the initiation of RNA chains take place in this system. A significant amount of the synthesized VPg-pU is found in the free form. The predominant product of the de novo initiation is represented by short phenol-soluble VPg oligonucleotide species, and only a small percentage of the latter appear to be elongated into longer RNA chains.

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