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. 1969 Feb;111(4):521-35.
doi: 10.1042/bj1110521.

The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability

P J Henderson, J D McGivan, J B Chappell

The action of certain antibiotics on mitochondrial, erythrocyte and artificial phospholipid membranes. The role of induced proton permeability

P J Henderson et al. Biochem J. 1969 Feb.

Abstract

1. The action of the antibiotics enniatin A, valinomycin, the actin homologues, gramicidin, nigericin and dianemycin on mitochondria, erythrocytes and smectic mesophases of lecithin-dicetyl hydrogen phosphate was studied. 2. These antibiotics induced permeability to alkali-metal cations on all three membrane systems. 3. The ion specificity on each membrane system was the same. 4. Enniatin A, valinomycin and the actins did not induce permeability to protons, whereas nigericin and dianemycin rendered all three membrane systems freely permeable to protons. 5. Several differences were noted between permeability induced by nigericin and that induced by gramicidin. 6. The action of all these antibiotics on mitochondrial respiration could be accounted for by changes in passive ion permeability of the mitochondrial membrane similar to those induced in erythrocytes and phospholipid membranes, if it is assumed that a membrane potential is present in respiring mitochondria.

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References

    1. Biochemistry. 1967 May;6(5):1360-9 - PubMed
    1. Biochem Biophys Res Commun. 1967 Feb 21;26(4):398-404 - PubMed
    1. Biochem Biophys Res Commun. 1967 Jul 21;28(2):277-83 - PubMed
    1. Arch Biochem Biophys. 1958 Dec;78(2):587-97 - PubMed
    1. Adv Enzymol Relat Areas Mol Biol. 1967;29:33-87 - PubMed