doi: 10.1084/jem.127.5.915.
Persistence of immunogenicity of antigen after uptake by macrophages
- PMID: 5655102
- PMCID: PMC2138486
- DOI: 10.1084/jem.127.5.915
Item in Clipboard
Persistence of immunogenicity of antigen after uptake by macrophages
J Exp Med.
.
Abstract
Peritoneal macrophages were cultured for several hours after uptake of (131)I-hemocyanin. The cells degraded most of the (131)I-labeled protein within 2-5 hr. Their ability to prime lymphocytes of syngeneic mice for a secondary immune challenge remained unchanged for long periods of time despite the loss of more than 90% of the original content of antigen. The persistence of immunogenicity was associated with a small percentage of antigen retained by the cell in a form which was protected from rapid breakdown and elimination.
Similar articles
-
The function of macrophages in the immune response.Semin Hematol. 1970 Apr;7(2):225-48. Semin Hematol. 1970. PMID: 4910220 Review. No abstract available.
-
The incidence of hemocyanin-binding cells in hemocyanin-tolerant rats.Cell Immunol. 1972 Jul;4(3):289-303. doi: 10.1016/0008-8749(72)90032-9. Cell Immunol. 1972. PMID: 5037348 No abstract available.
-
The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping.J Exp Med. 1971 Jul 1;134(1):224-41. doi: 10.1084/jem.134.1.224. J Exp Med. 1971. PMID: 4934148 Free PMC article.
-
The immunogenicity of antigen bound to the plasma membrane of macrophages.J Exp Med. 1970 Apr 1;131(4):711-25. doi: 10.1084/jem.131.4.711. J Exp Med. 1970. PMID: 5430785 Free PMC article.
-
The lymph-borne cells of the immune response: a review.Sci Basis Med Annu Rev. 1971:39-57. Sci Basis Med Annu Rev. 1971. PMID: 4933923 Review. No abstract available.
Cited by
-
Inflammatory response and antigen localization following immunization with influenza virus ISCOMs.Inflammation. 1989 Dec;13(6):641-9. doi: 10.1007/BF00914308. Inflammation. 1989. PMID: 2613292
-
Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation.Clin Exp Immunol. 1985 Jul;61(1):143-51. Clin Exp Immunol. 1985. PMID: 3876178 Free PMC article.
-
Antigen mediation of a late-acting suppressor T-cell activity.J Exp Med. 1977 Dec 1;146(6):1627-39. doi: 10.1084/jem.146.6.1627. J Exp Med. 1977. PMID: 303684 Free PMC article.
-
Cellular sites of immunologic unresponsiveness.Proc Natl Acad Sci U S A. 1970 Mar;65(3):551-6. doi: 10.1073/pnas.65.3.551. Proc Natl Acad Sci U S A. 1970. PMID: 4192271 Free PMC article.
-
Host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro.Infect Immun. 1978 Dec;22(3):758-62. doi: 10.1128/iai.22.3.758-762.1978. Infect Immun. 1978. PMID: 569645 Free PMC article.
