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. 1977 Jan;21(1):319-27.
doi: 10.1128/JVI.21.1.319-327.1977.

Induction of syncytia by Moloney murine leukemia virus in myoblasts defective in differentiation

P K Wong, P H Yuen, S J Kaufman

Induction of syncytia by Moloney murine leukemia virus in myoblasts defective in differentiation

P K Wong et al. J Virol. 1977 Jan.

Abstract

fu-1 cells, a nonfusing variant of the L8 line of rat myoblasts, form syncytia upon infection with murine leukemia virus (MuLV) or upon cocultivation with MuLV-infected cells; L8 cells do not form these syncytia, but do fuse into multinucleate myotubes. Syncytia of fu-1 cells form within 1 h after infection. The number of syncytia formed is proportional to the multiplicity of virus within a range of 4 to 16 and is maximum when the cell density is subconfluent. When either XC or fu-1 cells are productively infected with MuLV, they become resistant to syncytia formation by passage 3. The rapid formation of syncytia in fu-1 cells was found amenable for selection of temperature-sensitive mutants of MuLV and for screening additional variants of the L8 line.

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