Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1970 Dec 1;132(6):1267-78.
doi: 10.1084/jem.132.6.1267.

Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin

K U Hartmann

Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin

K U Hartmann. J Exp Med. .

Abstract

The immune response to foreign erythrocytes was studied in vitro. Two subpopulations of cells were prepared. One was a population of bone marrow-derived spleen cells, taken from thymectomized, irradiated, and bone marrow-reconstituted mice; there was evidence that most of the precursors of the PFC had been present in this cell population, but few PFC developed in cultures of these cells alone in the presence of immunogenic erythrocytes. Another cell suspension was made from spleens of mice which had been irradiated and injected with thymus cells and erythrocytes; these cells were called educated T cells. The two cell suspensions together allow the formation of PFC in the presence of the erythrocytes which were used to educate the T cells, but not in the presence of noncross-reacting erythrocytes. If bone marrow-derived cells and T cells were kept in culture together with two different species of erythrocytes, and if one of the erythrocytes had been used to educate the T cells, then PFC against each of the erythrocytes could be detected.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Soc Exp Biol Med. 1966 May;122(1):167-72 - PubMed
    1. J Exp Med. 1967 Sep 1;126(3):423-42 - PubMed
    1. Science. 1967 Dec 22;158(3808):1573-5 - PubMed
    1. Lancet. 1967 Dec 16;2(7529):1279-81 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Jan;59(1):296-303 - PubMed

Substances