Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Apr;93(4):1397-401.
doi: 10.1128/jb.93.4.1397-1401.1967.

Glucose-lactose diauxie in Escherichia coli

W F Loomis Jr, B Magasanik

Glucose-lactose diauxie in Escherichia coli

W F Loomis Jr et al. J Bacteriol. 1967 Apr.

Abstract

Growth of Escherichia coli in medium containing glucose, at a concentration insufficient to support full growth, and containing lactose, is diauxic. A mutation in the gene, CR, which determines catabolite repression specific to the lac operon, was found to relieve glucose-lactose but not glucose-maltose diauxie. Furthermore, a high concentration of lactose was shown to overcome diauxie in a CR(+) strain. Studies on the induction of beta-galactosidase by lactose suggested that glucose inhibits induction by 10(-2)m lactose. Preinduction of the lac operon was found to overcome this effect. The ability of glucose to prevent expression of the lac operon by reducing the internal concentration of inducer as well as by catabolite repression is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1956 Oct 13;178(4537):801-2 - PubMed
    1. J Mol Biol. 1964 Mar;8:417-26 - PubMed
    1. J Bacteriol. 1959 Nov;78:624-35 - PubMed
    1. Biochim Biophys Acta. 1964 Oct 23;92:85-94 - PubMed
    1. Biochem Biophys Res Commun. 1965 Jul 12;20(2):230-4 - PubMed

LinkOut - more resources