Properties of protective malarial antibody
Abstract
Properties of protective malarial antibody have been studied in cultures of P. knowlesi giving average parasite multiplication rates of sixfold in 24 hours. Parasite growth was assessed by incorporation of [3H]-leucine into protein.
Immune serum has little effect upon the growth of intracellular parasites, but prevents reinvasion of red cells and inhibits the succeeding cycle of parasite development. Protective antibody is present in relatively low titre in immune sera even after long immunization and this may explain certain characteristic features of malarial immunity.
Protective antibody in the sera studied is associated with IgG and IgM; its action is not complement dependent, but requires at least two combining sites per molecule. Anti-malarial antibody has several features in common with viral neutralizing antibody.
Similar articles
-
Properties of protective malarial antibody.Nature. 1970 Feb 21;225(5234):732-4. doi: 10.1038/225732a0. Nature. 1970. PMID: 4189798 No abstract available.
-
Serum antibody in acquired malarial immunity.Trans R Soc Trop Med Hyg. 1971;65(2):125-35. doi: 10.1016/0035-9203(71)90210-0. Trans R Soc Trop Med Hyg. 1971. PMID: 4934028 Review. No abstract available.
-
Symposium. The role of serum antibodies in malarial immunity. The detection and measurement of malarial antibodies.Trans R Soc Trop Med Hyg. 1971;65(2):111-24. doi: 10.1016/0035-9203(71)90209-4. Trans R Soc Trop Med Hyg. 1971. PMID: 4934027 Review. No abstract available.
-
Action of malarial antibody in vitro.Nature. 1969 Jul 26;223(5204):368-71. doi: 10.1038/223368a0. Nature. 1969. PMID: 4980851 No abstract available.
-
Studies on the immunology of human malaria. II. Characterization of antibodies to Plasmodium falciparum infections.Clin Exp Immunol. 1969 Jul;5(1):17-27. Clin Exp Immunol. 1969. PMID: 4892613 Free PMC article.
Cited by
-
Killing of blood-stage murine malaria parasites by hydrogen peroxide.Infect Immun. 1983 Jan;39(1):456-9. doi: 10.1128/iai.39.1.456-459.1983. Infect Immun. 1983. PMID: 6822428 Free PMC article.
-
[Culture technics applicable to erythrocyte stages of paludism parasites].Bull World Health Organ. 1973;48(3):355-72. Bull World Health Organ. 1973. PMID: 4583052 Free PMC article. No abstract available.
-
Antigenic variation and protective immunity in Plasmodium knowlesi malaria.Immunology. 1972 Oct;23(4):503-21. Immunology. 1972. PMID: 4628462 Free PMC article.
-
Immunization of rhesus monkeys with blood-stage antigens of Plasmodium knowlesi.Bull World Health Organ. 1979;57 Suppl 1(Suppl):139-51. Bull World Health Organ. 1979. PMID: 120763 Free PMC article.
-
T and B cell population changes in young and in adult rats infected with Plasmodium berghei.Infect Immun. 1976 Jul;14(1):178-83. doi: 10.1128/iai.14.1.178-183.1976. Infect Immun. 1976. PMID: 780272 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources