Skip to main page content
U.S. flag

An official website of the United States government

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1972 Sep;2(3):147-55.
doi: 10.1128/AAC.2.3.147.

An effect of hydroxyurea on Staphylococcus epidermidis: temporary loss of viability

An effect of hydroxyurea on Staphylococcus epidermidis: temporary loss of viability

R R Feiner et al. Antimicrob Agents Chemother. 1972 Sep.

Abstract

Although hydroxyurea (HU) is recognized as a specific inhibitor of deoxyribonucleic acid (DNA) synthesis, it did not have this effect in a strain of Staphylococcus epidermidis. In this case, HU caused a loss of colony-forming ability but did not prevent cell division in liquid medium. DNA synthesis apparently was affected only secondarily. About 10% of the population recovered colony-forming ability during the latter part of the growth cycle or when growth was slowed by chloramphenicol. Recovery also occurred when HU was removed from the medium. HU prevented cellular autolysis.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Gen Microbiol. 1970 May;61(2):155-71 - PubMed
    1. J Mol Biol. 1970 Apr 28;49(2):433-9 - PubMed
    1. J Bacteriol. 1971 Feb;105(2):565-72 - PubMed
    1. J Biol Chem. 1971 Mar 25;246(6):1820-7 - PubMed
    1. J Bacteriol. 1971 Mar;105(3):1175-83 - PubMed

LinkOut - more resources