Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Apr;9(4):696-701.
doi: 10.1128/iai.9.4.696-701.1974.

Effect of tetanolysin on platelets and lysosomes

C B Cox, C Hardegree, R Fornwald

Effect of tetanolysin on platelets and lysosomes

C B Cox et al. Infect Immun. 1974 Apr.

Abstract

Tetanolysin, partially purified, caused the lysis of human and rabbit platelets, as determined by a decrease in the optical density of platelet suspensions and the release of serotonin, enzymes, and protein. This lytic activity was neutralized by antitoxin. In addition, a suspension of the lysosome-containing large granule fraction of rabbit liver released hydrolytic enzymes when exposed to tetanolysin. Thus, tetanolysin can be added to the list of bacterial toxins that are lytic for a variety of cellular or subcellular membranes. These findings provide additional data that suggest that tetanolysin may contribute to the pathogenesis of some of the unusual manifestations observed in clinical tetanus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Lab Clin Med. 1970 May;75(5):840-55 - PubMed
    1. J Pathol Bacteriol. 1965 Jan;89:209-23 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1973;276(3-4):447-60 - PubMed
    1. J Infect Dis. 1972 Sep;126(3):294-340 - PubMed
    1. J Bacteriol. 1966 May;91(5):1677-80 - PubMed

LinkOut - more resources