doi: 10.1128/jb.110.2.616-623.1972.
Physiological factors in the regulation of alkaline phosphatase synthesis in Escherichia coli
- PMID: 4553839
- PMCID: PMC247456
- DOI: 10.1128/jb.110.2.616-623.1972
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Physiological factors in the regulation of alkaline phosphatase synthesis in Escherichia coli
J Bacteriol.
1972 May.
Abstract
Alkaline phosphatase is induced in excess phosphate media by starvation either for pyrimidines or for guanine. Induction is observed both during starvation, after a lag period, and following a period of starvation. Induction is not caused by a lowering of the internal orthophosphate pool, but is linked to alterations in the levels of the nucleotide pools. Experiments with purine-requiring mutants suggest that phosphatase is induced in wild-type strains by an adenine nucleotide. Mutations in the phoR gene can produce differential responses to the different starvation regimes.
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