doi: 10.1126/science.182.4112.592.
Rapid viral induction of plasmacytomas in pristane-primed BALB-c mice
- PMID: 4355680
- DOI: 10.1126/science.182.4112.592
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Rapid viral induction of plasmacytomas in pristane-primed BALB-c mice
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Abstract
Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin-producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone.
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