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. 1969 Jul;63(3):753-8.
doi: 10.1073/pnas.63.3.753.

Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture

V Klement, W P Rowe, J W Hartley, W E Pugh

Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture

V Klement et al. Proc Natl Acad Sci U S A. 1969 Jul.

Abstract

Tissue culture cells of a Rous virus-induced rat tumor undergo syncytium formation when placed in contact with mouse embryo cell cultures infected with murine leukemia viruses. This phenomenon can be used as a cytopathic end point for isolating and titrating these viruses in tissue culture. The principle should be applicable to detection of leukemia viruses of other species.

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References

    1. Virology. 1967 Jan;31(1):176-8 - PubMed
    1. J Virol. 1968 Sep;2(9):865-8 - PubMed
    1. J Virol. 1969 Feb;3(2):126-32 - PubMed
    1. Folia Biol (Praha). 1963 Apr;9:77-81 - PubMed
    1. Nature. 1960 Jun 18;186:980-1 - PubMed