doi: 10.1038/316606a0.
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer
- PMID: 4033759
- DOI: 10.1038/316606a0
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Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer
Nature.
1985 Aug.
Abstract
We have introduced a full-length complementary DNA of the T-cell antigen receptor beta-chain into a mutant human T-cell line that lacked a complete beta-chain messenger RNA, had a diminished level of alpha-chain transcript and did not express surface T3- or antigen receptor. Expression of the transfected beta-chain led to a normal level of alpha-chain transcript and a structurally and functionally active T3 T-cell antigen receptor complex on the cell surface.
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