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. 1985 Jan;5(1):253-8.
doi: 10.1128/mcb.5.1.253-258.1985.

Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells

S M Frisch, J M Davidson, Z Werb

Blockage of tropoelastin secretion by monensin represses tropoelastin synthesis at a pretranslational level in rat smooth muscle cells

S M Frisch et al. Mol Cell Biol. 1985 Jan.

Abstract

The blockage of protein secretion in the R22 cultured rat aortic smooth muscle cell strain with monensin repressed tropoelastin gene expression at the mRNA level by ca. 50-fold as measured by biosynthetic pulse-labeling, in vitro translation, and hybridization with a tropoelastin genomic DNA probe. These results suggest that tropoelastin gene expression is autoregulated, and they represent the first reported effect of monensin on gene expression.

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References

    1. Cold Spring Harb Symp Quant Biol. 1982;46 Pt 1:171-83 - PubMed
    1. J Exp Med. 1980 Dec 1;152(6):1537-53 - PubMed
    1. Nature. 1983 Jul 7-13;304(5921):80-3 - PubMed
    1. Nature. 1983 Aug 18-24;304(5927):645-8 - PubMed
    1. Methods Enzymol. 1983;101:650-74 - PubMed

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