A prospective study of bone mass in patients with type I diabetes
- PMID: 3964795
- DOI: 10.1210/jcem-60-1-74
A prospective study of bone mass in patients with type I diabetes
Abstract
Sixty-nine patients with type I diabetes mellitus were followed for from 1-4 yr (mean, 3 yr). Their overall growth, as measured by height and weight, was normal; however, repeated measurements of their bone mass using photon absorptiometry and radiogrammetry showed that, relative to normal subjects, the patients had a persistent bone deficit throughout the course of the study. This deficit was not attributable to bone width, which was normal. On the average, the magnitude of the deficit did not change with time; furthermore, an individual's rate of change in bone mass deficit during the study was not correlated with the patient's glucose control, as measured by hemoglobin A-1 or fasting blood glucose levels. Initial levels of serum ionized calcium and magnesium were decreased in the patients with diabetes. During the study, the mean level of ionized calcium increased, but that of magnesium decreased further, compared to the initial values. In a group of 19 patients with newly diagnosed diabetes, bone mass was found to be significantly below normal among the girls, but not among the boys.
Similar articles
-
Evaluation of bone mass and growth in young diabetics.Metabolism. 1982 Aug;31(8):848-54. doi: 10.1016/0026-0495(82)90086-5. Metabolism. 1982. PMID: 6980356
-
Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus.Diabetes. 1988 Jan;37(1):8-12. doi: 10.2337/diab.37.1.8. Diabetes. 1988. PMID: 3335279
-
IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes.J Bone Miner Res. 2008 Dec;23(12):1884-91. doi: 10.1359/jbmr.080713. J Bone Miner Res. 2008. PMID: 18665784 Free PMC article.
-
Bone mineral metabolism in human type 1 (insulin dependent) diabetes mellitus.Dan Med Bull. 1988 Apr;35(2):109-21. Dan Med Bull. 1988. PMID: 3282809 Review.
-
Calcium homeostasis and mineralization in puberty.Dan Med Bull. 1989 Apr;36(2):113-24. Dan Med Bull. 1989. PMID: 2651027 Review.
Cited by
-
Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice.Endocrinology. 2005 Aug;146(8):3622-31. doi: 10.1210/en.2004-1677. Epub 2005 May 19. Endocrinology. 2005. PMID: 15905321 Free PMC article.
-
Glucose transport system in UMR-106-01 osteoblastic osteosarcoma cells: regulation by insulin.Calcif Tissue Int. 1989 Jul;45(1):27-33. doi: 10.1007/BF02556657. Calcif Tissue Int. 1989. PMID: 2504460
-
Calcitonin secretion in children with insulin-dependent diabetes mellitus.Eur J Pediatr. 1991 May;150(7):464-7. doi: 10.1007/BF01958422. Eur J Pediatr. 1991. PMID: 1915495
-
Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa.Bone. 2010 Mar;46(3):796-800. doi: 10.1016/j.bone.2009.11.014. Epub 2009 Nov 18. Bone. 2010. PMID: 19931436 Free PMC article.
-
Effects of advanced glycation end-products on the proliferation and differentiation of osteoblast-like cells.Mol Cell Biochem. 1997 May;170(1-2):43-51. doi: 10.1023/a:1006816223292. Mol Cell Biochem. 1997. PMID: 9144317
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
