Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 22.
doi: 10.1007/s12035-024-04613-7. Online ahead of print.

The Role of Ion-Transporting Proteins on Crosstalk Between the Skeletal Muscle and Central Nervous Systems Elicited by Physical Exercise

Judit Borràs Bertomeu  1   2 , Letícia Paiva Fioravanço  1   2 , Thiago Rozales Ramis  1   2 , Douglas Buchmann Godinho  1   2 , Alexandre Seixas Nascimento  1   2 , Gabriel Corrêa Lima  1   2 , Ana Flavia Furian  3 , Mauro Schneider Oliveira  3 , Michele Rechia Fighera  1   2   4 , Luiz Fernando Freire Royes  5   6   7
Affiliations
Review

The Role of Ion-Transporting Proteins on Crosstalk Between the Skeletal Muscle and Central Nervous Systems Elicited by Physical Exercise

Judit Borràs Bertomeu et al. Mol Neurobiol. .

Abstract

A paradigm shift in the understanding of bidirectional interactions between peripheral and central nervous systems is essential for development of rehabilitation and preventive interventions based on physical exercise. Although a causal relationship has not been completely established, modulation of voltage-dependent ion channels (Ca2+, Cl-, K+, Na+, lactate-, H+) in skeletal and neuronal cells provides opportunities to maintain force production during exercise and reduce the risk of disease. However, there are caveats to consider when interpreting the effects of physical exercise on this bidirectional axis, since exercise protocol details (e.g., duration and intensity) have variable effects on this crosstalk. Therefore, an integrative perspective of the skeletal muscle and brain's communication pathway is discussed, and the role of physical exercise on such communication highway is explained in this review.

Keywords: Central nervous system; Group III/IV afferent neurons; K+ ATPase; Na+; Peripheral nervous system; Physical exercise; Voltage-dependent ions channels.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Consent for Publication: Not applicable. Competing Interests: The authors declare no competing interests.

Similar articles

See all similar articles

References

    1. Kramer A (2020) An overview of the beneficial effects of exercise on health and performance. Adv Exp Med Biol 1228:3–22 - PubMed - DOI
    1. Hargreaves M, Spriet LL (2020) Skeletal muscle energy metabolism during exercise. Nat Metab 2(9):817–828 - PubMed - DOI
    1. McKenna MJ, Bangsbo J, Renaud JM (2008) Muscle K+, Na+, and Cl disturbances and Na+-K+ pump inactivation: implications for fatigue. J Appl Physiol 104(1):288–95 - PubMed - DOI
    1. Gadoth N, Göbel H (2011) Oxidative stress and free radical damage in neurology. Humana Press, New York - DOI
    1. Bangsbo J et al (2001) ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise. Am J Physiol Endocrinol Metab 280(6):E956–E964 - PubMed - DOI

LinkOut - more resources