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Review
. 2024 Oct 30:26:981-989.
doi: 10.1016/j.reth.2024.09.014. eCollection 2024 Jun.

Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery

Quynh Dieu Trinh  1 , Huynh Nhu Mai  2 , Duc Toan Pham  3
Affiliations
Review

Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery

Quynh Dieu Trinh et al. Regen Ther. .

Abstract

Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been widely studied. However, current therapeutics only reduce the symptoms and do not ameliorate the pathogenesis of these diseases. Recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. Mesenchymal stem cells (MSCs) exert anti-apoptotic, anti-inflammatory, and antioxidative effects. Therefore, investigating the effects of MSCs and their applications may lead to the discovery of more effective therapies for neurodegenerative diseases. In this study, we review different approaches used to identify therapies for neurodegenerative diseases using MSCs.

Keywords: Antibody drugs; Circadian rhythm; Mesenchymal stem cells; Neurodegenerative diseases; Neuroinflammation; Stem cell therapy.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Mechanism of MSCs and MSC-exos therapy in treatment of neurodegenerative diseases.
Fig. 2
Fig. 2
MSCs application as antibody drug delivery system in treatment of neurodegenerative diseases.
Fig. 3
Fig. 3
Challenges of MSCs and MSC-exos therapy in treatment of neurodegenerative diseases in practice.
See this image and copyright information in PMC

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