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Case Reports
. 2024 Oct 7;16(10):e71020.
doi: 10.7759/cureus.71020. eCollection 2024 Oct.

Spontaneous Regression of a Large Gastric Adenoma Following Gynecologic Surgery

Stamatina Vogli  1 , Panagiotis Markopoulos  1 , Aikaterini Filippakou  1 , Gabriela Stanc  2 , Eftychia Tsironi  1 , Emmanouil Telakis  1
Affiliations
Case Reports

Spontaneous Regression of a Large Gastric Adenoma Following Gynecologic Surgery

Stamatina Vogli et al. Cureus. .

Abstract

Gastric adenomas are defined as polypoid lesions of neoplastic epithelium in the stomach. They are rare, occurring much less frequently than fundic gland polyps and hyperplastic polyps, and are typically associated with mucosal atrophy and intestinal metaplasia. Gastric adenomas also carry a risk of malignant transformation. We report a case of a 66-year-old woman with a gastric adenoma of the corpus found during a preoperative esophagogastroduodenoscopy before abdominal surgery for an ovarian tumor. The patient demonstrated spontaneous regression of her gastric adenoma 14 months after her initial endoscopy and subsequent hysterectomy with salpingo-oophorectomy without undergoing endoscopic resection or any other intervention. To our knowledge, this is the first well-documented case of spontaneous regression of a gastric adenoma.

Keywords: gastric adenoma; gastric polyp; hysterectomy with salpingo-oophorectomy; serous borderline ovarian tumor; spontaneous regression.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. A large gastric adenoma in the proximal stomach as seen with (a) high-definition white-light endoscopy and (b) virtual chromoendoscopy using blue light imaging.
Figure 2
Figure 2. Polypoid dysplastic columnar epithelium with hyperchromatic elongated nuclei in keeping with gastric adenoma, intestinal type, with low-grade dysplasia (H&E, X100).
Figure 3
Figure 3. Complete regression of the gastric adenoma with a small, slightly depressed area noted at the site as seen with (a) high-definition white-light endoscopy, (b) blue light imaging, and (c, d) chromoendoscopy with methylene blue.
Figure 4
Figure 4. Twenty months after the index endoscopy, only a small irregular area at the site of the adenoma with irregular microvessels in the center is seen with (a) high-definition white-light endoscopy, (b) blue light imaging, (c) high-definition white-light endoscopy with electronic magnification X1.5, and (d) blue light imaging with electronic magnification X1.5.
Figure 5
Figure 5. Atrophy of gastric mucosa with focal pseudopyloric metaplasia and a mixed chronic inflammatory infiltrate; (a) H&E X40, (b) H&E X100.
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