Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 3;4(6):754-761.
doi: 10.21873/cdp.10392. eCollection 2024 Nov-Dec.

High Subcutaneous Adipose Tissue Radiodensity Predicts Poor Prognosis in Patients With Gastric Cancer

Shinichiro Iida  1 , Yasunori Matsumoto  1 , Takeshi Toyozumi  1 , Ryota Otsuka  1 , Tadashi Shiraishi  1 , Hiroki Morishita  1 , Tenshi Makiyama  1 , Yuri Nishioka  1 , Masanari Yamada  1 , Atsushi Hirata  1 , Koichi Hayano  1 , Gaku Ohira  1 , Masayuki Kano  1   2 , Hisahiro Matsubara  1
Affiliations

High Subcutaneous Adipose Tissue Radiodensity Predicts Poor Prognosis in Patients With Gastric Cancer

Shinichiro Iida et al. Cancer Diagn Progn. .

Abstract

Background/aim: Although the impact of body composition on cancer treatment outcomes of patients with cancer has been increasingly reported, it is still unclear whether the radiodensity of subcutaneous adipose tissue (SAT) on computed tomography (CT) images has a prognostic impact on patients with gastric cancer. We measured muscle and SAT profiles on CT and performed an integrated analysis with clinicopathologic factors.

Patients and methods: We retrospectively analyzed 230 patients with gastric cancer who underwent gastrectomy between June 2016 and December 2020. SAT radiodensity (SAT-R), and skeletal muscle index (SMI) were measured in preoperative CT images. These were compared with clinicopathologic factors, overall survival (OS), and recurrence-free survival (RFS).

Results: High SAT-R was significantly associated with older age (p=0.003) and lower BMI, lymphocyte, hemoglobin, γ-GTP, cholinesterase, albumin, and triglyceride values (p<0.001, <0.001, 0.027, 0.032, <0.001, 0.001, and <0.001, respectively). In the univariate analysis, high SAT-R, and low SMI were significantly associated with poor OS (p=0.003 and <0.001) and poor RFS (p=0.014 and 0.011). In the multivariate analysis by Cox proportional hazard model, high SAT-R and low SMI were identified as independent prognostic factors for poor OS (p=0.037 and 0.007).

Conclusion: High SAT-R on preoperative CT was associated with poor OS in patients with gastric cancer after gastrectomy. SAT-R has a potential to be a novel prognostic marker for surgically treated patients with gastric cancer.

Keywords: Adipose tissue radiodensity; gastric cancer; skeletal muscle index; survival.

PubMed Disclaimer

Conflict of interest statement

All Authors declare no conflicts of interest in relation to this study.

Figures

Figure 1
Figure 1
Adipose tissue radiodensity difference according to sex. There was no significant difference according to sex in subcutaneous adipose tissue radiodensity (SAT-R). Visceral adipose tissue radiodensity (VAT-R) was significantly higher in females.
Figure 2
Figure 2
Kaplan–Meier overall survival (OS) and recurrence-free survival (RFS) curves according to subcutaneous adipose tissue radiodensity (SAT-R) radiodensity and skeletal muscle index (SMI). Kaplan–Meier OS curves according to SAT-R (A) and SMI (C). Kaplan–Meier RFS curves according to SAT-R (B) and SMI (D). OS and RFS were significantly worse in the high SAT-R and low SMI groups than in the other groups.
Figure 3
Figure 3
Kaplan–Meier overall survival (OS) curves according to the combination of subcutaneous adipose tissue radiodensity and skeletal muscle index. OS was significantly worse in patients with two factors compared with others.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Ito Y, Miwa T, Kanda M, Ito S, Mochizuki Y, Teramoto H, Ishigure K, Murai T, Asada T, Ishiyama A, Matsushita H, Tanaka C, Kobayashi D, Fujiwara M, Murotani K, Kodera Y. Risk score for predicting death from other causes after curative gastrectomy for gastric cancer. Gastric Cancer. 2023;26(2):317–323. doi: 10.1007/s10120-022-01354-1. - DOI - PubMed
    1. Nunobe S, Oda I, Ishikawa T, Akazawa K, Katai H, Isobe Y, Miyashiro I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Suzuki S, Kakeji Y, Registration Committee of the Japanese Gastric Cancer Surgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer Association. Gastric Cancer. 2020;23:328–338. doi: 10.1007/s10120-019-01000-3. - DOI - PubMed
    1. Yoon SB, Choi MH, Song M, Lee JH, Lee IS, Lee MA, Hong TH, Jung ES, Choi MG. Impact of preoperative body compositions on survival following resection of biliary tract cancer. J Cachexia Sarcopenia Muscle. 2019;10(4):794–802. doi: 10.1002/jcsm.12431. - DOI - PMC - PubMed
    1. Rinninella E, Cintoni M, Raoul P, Pozzo C, Strippoli A, Bria E, Tortora G, Gasbarrini A, Mele MC. Muscle mass, assessed at diagnosis by L3-CT scan as a prognostic marker of clinical outcomes in patients with gastric cancer: Asystematic review and meta-analysis. Clinical Nutrition. 2020;39(7):2045–2054. doi: 10.1016/j.clnu.2019.10.021. - DOI - PubMed

LinkOut - more resources