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. 1979 Dec;17(6):361-5.
doi: 10.1007/BF01236270.

Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide

F Malaisse-Lagae, Y Stefan, J Cox, A Perrelet, L Orci

Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide

F Malaisse-Lagae et al. Diabetologia. 1979 Dec.

Abstract

Systematic sampling of human necropsy pancreases has revealed that pancreatic polypeptide (PP) cells are not distributed equally in the gland. PP-cells are the most abundant cell type in the posterior part of the pancreatic head while they are scarce or absent in the remainder of the gland. The PP-rich part of the head can be separated by blunt dissection from the pancreas as a discrete lobe. This lobe probably originates from the ventral pancreatic bud during embryogenesis. A quantitative study of the immunofluorescent endocrine cell types (insulin, glucagon, somatostatin and pancreatic polypeptide cells) in PP-rich and PP-poor regions of pancreases in 8 subjects with ages ranging from 33 fetal weeks to 80 years, showed that the proportions of the cell types were different in youngs and adults.

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