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. 2024 Dec;41(12):3423-3432.
doi: 10.1007/s10815-024-03299-z. Epub 2024 Nov 4.

ICSI and PGT-A in PCOS phenotype-D patients: a matched case-control study versus idiopathic infertile women

Alberto Vaiarelli  1 , Danilo Cimadomo  2 , Cecilia Rucci  3 , Federica Innocenti  2 , Marilena Taggi  2 , Erika Pittana  2   3 , Giulia Fiorentino  4 , Pasquale Petrone  3 , Daria Maria Soscia  2   5 , Gemma Fabozzi  2   6   5 , Rossella Mazzilli  2   7 , Laura Rienzi  2   8 , Filippo Maria Ubaldi  2 , Rossella Elena Nappi  9   10 , Gianluca Gennarelli  11   12
Affiliations

ICSI and PGT-A in PCOS phenotype-D patients: a matched case-control study versus idiopathic infertile women

Alberto Vaiarelli et al. J Assist Reprod Genet. 2024 Dec.

Abstract

Purpose: To assess oocyte competence and embryo chromosomal constitution in phenotype-D PCOS women undergoing ICSI for PGT-A at the blastocyst stage.

Methods: Retrospective study at a private IVF center. In the period 2013-2021, 58 naïve phenotype-D PCOS women (i.e., oligomenorrhea, ovarian PCO-morphology, and absence of hyperandrogenism) underwent ICSI with ejaculated sperm for PGT-A. These cases were matched to 58 controls selected from 2211 naïve women with idiopathic infertility planned for the same treatment in the same period. The matching variables were age (≈ 36 years), BMI (≈ 22), cumulus oocyte complexes (COCs) retrieved (≈ 21-23), and sperm quality (≈ 43-45% men with all sperm parameters > 5th percentile). The primary outcome was euploid blastocyst rate (EBR) per cohort of inseminated oocytes.

Results: Maturation rates per COCs and euploidy per biopsied blastocysts were similar. PCOS patients with phenotype-D showed higher fertilization per inseminated oocytes and higher blastulation per zygotes. This resulted into a higher EBR per inseminated oocytes and more euploid blastocysts available for transfer, although these differences adjusted for confounders were not significant. The live birth rate per first euploid transfers was comparable, so were all other outcomes considered.

Conclusions: Oocyte competence was not compromised in phenotype-D PCOS women, while good prognosis idiopathic infertile women might have unknown oocyte issues. In case of repeated failures after intrauterine insemination, a timely referral to IVF might represent an efficient strategy, in line with the "one-and-done" approach fulfilling a family planning perspective. Indeed, 22% of the phenotype-D PCOS women had 2 singleton LBs and 76% had surplus oocytes/euploid blastocysts after achieving ≥ 1 live birth.

Keywords: Blastocyst; Euploid; Oocyte competence; PCOS phenotype-D; PGT-A.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

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References

    1. Sanchez-Garrido MA, Tena-Sempere M. Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies. Mol Metab. 2020;35:100937. - PMC - PubMed
    1. Abraham Gnanadass S, Divakar Prabhu Y, Valsala GA. Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update. Arch Gynecol Obstet. 2021;303:631–43. - PubMed
    1. Dason ES, Koshkina O, Chan C, Sobel M. Diagnosis and management of polycystic ovarian syndrome. CMAJ. 2024;196:E85–94. - PMC - PubMed
    1. Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, et al. Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Eur J Endocrinol. 2023;189:G43–64. - PubMed
    1. Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum Reprod. 2018;33:1602–18. - PMC - PubMed

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