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. 2024 Oct 28:119:e240140.
doi: 10.1590/0074-02760240140. eCollection 2024.

The Oxente Chagas Bahia Project: evaluating the efficacy of a rapid diagnostic test and treatments for Chagas disease

Fred Luciano Neves Santos  1   2   3 , Tycha Bianca Sabaini Pavan  1   2 , Cristiane Siqueira Valle  4 , Daniel Dias Sampaio  2 , Larissa Carvalho Medrado Vasconcelos  1   2 , Maria Hermoso Cristóbal  4 , Ângelo Antônio Oliveira Silva  1   2 , Cátia Martins de Oliveira  5 , Raquel Santos de Souza  5 , Carmen Nila Phang Romero Casas  5 , André Daher  3   4 , Isadora Cristina de Siqueira  2   3   6
Affiliations

The Oxente Chagas Bahia Project: evaluating the efficacy of a rapid diagnostic test and treatments for Chagas disease

Fred Luciano Neves Santos et al. Mem Inst Oswaldo Cruz. .

Abstract

Chagas disease (CD), caused by Trypanosoma cruzi, is a life-threatening neglected anthropozoonosis primarily transmitted by triatomine bugs. Affecting an estimated 5.7 million people globally, CD has significant morbidity and mortality, particularly in Latin America. The Oxente Chagas Bahia Project aims to screen approximately 30,000 individuals, validate a rapid diagnostic test in a real-world setting, and provide crucial data on its diagnostic performance and cost-effectiveness. Additionally, a biobank will be established to support further research on disease biomarkers and treatment cure rates. By enhancing access to timely diagnosis and treatment, the project will evaluate a strategy to reduce the CD burden.

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Conflict of interest statement

All authors provided critical feedback and contributed to the conceptualisation, analysis, and preparation of the manuscript. The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation. The authors declare that no competing interests.

Figures

None
Flowchart illustrating the study design. The study is divided into three steps: (A) seroepidemiological survey using TR Chagas Bio-Manguinhos of residents in Tremedal and Novo Horizonte, Bahia; (B) evaluation of the diagnostic performance and cost-effectiveness of the TR Chagas Bio-Manguinhos for serological screening in a real-world setting; and (C) prospective cohort study assessing the safety and efficacy of Chagas disease treatments.
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References

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Substances

Grants and funding

Financial support: INOVA Fiocruz Pesquisa Clínica em Doença de Chagas (VPPCB-001-FIO-22-2-11), FAPESB/SECTI (Universal, proposal NºAPP0007/2023). ICS and FLNS are CNPq research grantees (process numbers 316456/2021-7 and 309263/2020-4, respectively).