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. 2024 Oct 1;60(10):1605.
doi: 10.3390/medicina60101605.

Mitochondrial DNA Copy Number Is Associated with the Severity of Irritable Bowel Syndrome

Soo-Jung Jung  1   2 , Jae-Ho Lee  3 , Ji-Yeon Lim  4 , Yun-Yi Yang  5
Affiliations

Mitochondrial DNA Copy Number Is Associated with the Severity of Irritable Bowel Syndrome

Soo-Jung Jung et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Irritable bowel syndrome (IBS), as a gastrointestinal disorder, presents with abdomen pain and alterations in the bowel habits. Its pathogenesis remains unclear. Here, we examined mitochondrial DNA copy number (mtCN) in IBS and its clinical value. Materials and Methods: mtCN was analyzed in 43 IBS patients using quantitative real-time polymerase chain reaction. Furthermore, data on the clinical characteristics of patients and symptom severity of IBS were collected, and their association with mtCN was analyzed. Results: mtCN was higher in patients with IBS (p = 0.008) and those with a drinking habit (p = 0.004). Smoking and the presence of a sleep partner showed a possible association with mtCN; however, it did not reach significance. The severity of IBS symptoms tended to positively correlate with mtCN (r = 0.279, p = 0.070). Conclusions: Overall, we demonstrated a potential association between mtCN and the clinicopathologic characteristics of patients with IBS. Further studies considering genetic and clinical factors are required.

Keywords: irritable bowel syndrome; mitochondria; mitochondria content; mitochondrial DNA copy number.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Positive correlation between the severity of IBS symptoms and mtCN.
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References

    1. Canavan C., West J., Card T. The epidemiology of irritable bowel syndrome. Clin. Epidemiol. 2014;6:71–80. doi: 10.2147/CLEP.S40245. - DOI - PMC - PubMed
    1. Liu Y., Liu L., Yang Y., He Y., Zhang Y., Wang M., Chen S., Yao S. A school-based study of irritable bowel syndrome in medical students in Beijing, China: Prevalence and some related factors. Gastroenterol. Res. Pract. 2014;2014:124261. doi: 10.1155/2014/124261. - DOI - PMC - PubMed
    1. Shiotani A., Miyanishi T., Takahashi T. Sex differences in irritable bowel syndrome in Japanese university students. J. Gastroenterol. 2006;41:562–568. doi: 10.1007/s00535-006-1805-2. - DOI - PubMed
    1. Cain K.C., Headstrom P., Jarrett M.E., Motzer S.A., Park H., Burr R.L., Surawicz C.M., Heitkemper M.M. Abdominal pain impacts quality of life in women with irritable bowel syndrome. Am. J. Gastroenterol. 2006;101:124–132. doi: 10.1111/j.1572-0241.2006.00404.x. - DOI - PubMed
    1. Yang Y.-Y., Jun S. Prevalence and associated factors of insomnia in college students with irritable bowel syndrome. Korean J. Adult Nurs. 2018;30:235–244. doi: 10.7475/kjan.2018.30.3.235. - DOI

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Grants and funding

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number) (NRF-2022R1I1A1A01068949 and RS-2024-00463771-0-1).

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