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Meta-Analysis
. 2024 Oct 24;14(1):25209.
doi: 10.1038/s41598-024-75090-0.

Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: a meta-analysis of randomized controlled trials

Yalong Li #  1 , Xingtong Wang #  1 , Yucong Li #  1 , Dawei Li  1 , Shijie Li  1 , Chuanan Shen  2
Affiliations
Meta-Analysis

Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: a meta-analysis of randomized controlled trials

Yalong Li et al. Sci Rep. .

Abstract

Allogeneic platelet-rich plasma (al-PRP) is gaining attention in clinical practice for treating chronic refractory wounds, though research results remain controversial. To assess the clinical efficacy of al-PRP for chronic refractory wounds. Databases including PubMed, Cochrane Library, Embase, CNKI, SinoMed, VIP, and WFPD were searched for randomized controlled trials comparing al-PRP with conventional treatments up to October 2023. Two researchers independently screened studies, extracted data, and assessed quality. Statistical analysis was conducted using RevMan 5.4, and potential publication bias was assessed and corrected using funnel plots and Egger's test. Twelve studies with 717 cases were included. Meta-analysis showed al-PRP significantly improved outcomes compared to non-al-PRP treatments: increased healing rate (RR 2.72, 95% CI 1.77-4.19, p < 0.00001), shortened healing time (SMD - 1.03, 95% CI -1.31 to -0.75, p < 0.00001), improved efficacy rate (RR 1.19, 95% CI 1.10-1.28, p < 0.00001), increased wound shrinkage (MD 35.65%, 95% CI 21.65-49.64, p < 0.00001), and reduced hospital stays (MD -2.62, 95% CI -4.35 to -0.90, p = 0.003). Al-PRP is a feasible, effective, and safe biological therapy for chronic refractory wounds.Trial registration: PROSPERO Identifier CRD42022374920.

Keywords: Allogeneic; Chronic refractory wounds; Clinical effect; Meta-analysis; Platelet-rich plasma; Ulcers.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of studies screening.
Fig. 2
Fig. 2
Summary of bias risk of the included studies (Note: “?” represents uncertain risk ,“+” represents low risk and “-” represents high risk).
Fig. 3
Fig. 3
Bias risk of the included studies.
Fig. 4
Fig. 4
Healing rate of chronic refractory wounds.
Fig. 5
Fig. 5
Healing time of chronic refractory wounds.
Fig. 6
Fig. 6
Efficacy rate of chronic refractory wounds.
Fig. 7
Fig. 7
Wound shrinkage rate of chronic refractory wounds.
Fig. 8
Fig. 8
Hospital stay of patients with chronic refractory wounds.
Fig. 9
Fig. 9
Funnel plot of publication bias of included studies.
Fig. 10
Fig. 10
Egger’s test of included studies.
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