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Review
. 2024 Sep 26:14:1443256.
doi: 10.3389/fonc.2024.1443256. eCollection 2024.

Targeting the ubiquitin-proteasome system: a novel therapeutic strategy for neuroblastoma

Yangshen He #  1 , Jianing Wang #  2 , Tiantian Xiao  1
Affiliations
Review

Targeting the ubiquitin-proteasome system: a novel therapeutic strategy for neuroblastoma

Yangshen He et al. Front Oncol. .

Abstract

Neuroblastoma (NB) stands as a common and formidable malignant tumor among children, characterized by marked tumor heterogeneity and resistance to conventional treatments. Central to the regulation of protein stability, localization, and function is the process of ubiquitination-a critical protein modification. The therapeutic potential of drugs that target deubiquitination, demonstrated in the treatment of refractory multiple myeloma, warrants investigation in the context of NB. This review endeavors to demystify the intricate biological implications of ubiquitination within NB pathology, synthesize the current landscape of preclinical studies focused on the inhibition of the ubiquitin-proteasome system in NB, and assess the viability of this strategy as an innovative therapeutic frontier.

Keywords: cancer therapy; neuroblastoma; proteasome inhibition; targeted therapy; ubiquitination.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Min J, Wu Y, Huang S, Li Y, Lv X, Tang R, et al. . Serum cholesterol level as a predictive biomarker for prognosis of Neuroblastoma. BMC Pediatr. (2024) 24:205. doi: 10.1186/s12887-024-04700-7 - DOI - PMC - PubMed
    1. Tan J, Wang C, Jin Y, Xia Y, Gong B, Zhao Q. Optimal combination of MYCN differential gene and cellular senescence gene predicts adverse outcomes in patients with neuroblastoma. Front Immunol. (2023) 14:1309138. doi: 10.3389/fimmu.2023.1309138 - DOI - PMC - PubMed
    1. Hu X, Zhou Y, Hill C, Chen K, Cheng C, Liu X, et al. . Identification of MYCN non-amplified neuroblastoma subgroups points towards molecular signatures for precision prognosis and therapy stratification. Br J Cancer. (2024) 130:1841–54. doi: 10.1038/s41416-024-02666-y - DOI - PMC - PubMed
    1. Bellini A, Potschger U, Bernard V, Lapouble E, Baulande S, Ambros PF, et al. . Frequency and prognostic impact of ALK amplifications and mutations in the European neuroblastoma study group (SIOPEN) high-risk neuroblastoma trial (HR-NBL1). J Clin Oncol: Off J Am Soc Clin Oncol. (2021) 39:3377–90. doi: 10.1200/JCO.21.00086 - DOI - PMC - PubMed
    1. Li H, Zhao J, Yang J, Tang J, Zhang T, Jiang H, et al. . Bone marrow relapse in stage 4 neuroblastoma of children in Shanghai. Am J Cancer Res. (2024) 14:145–54. doi: 10.62347/ZMWQ3581 - DOI - PMC - PubMed

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