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Review
. 2024 Nov;281(Pt 1):136198.
doi: 10.1016/j.ijbiomac.2024.136198. Epub 2024 Oct 2.

Functional and pathological roles of adenylyl cyclases in various diseases

Ying Gao  1 , Yanqun Luo  2 , Guang Ji  3 , Tao Wu  4
Affiliations
Review

Functional and pathological roles of adenylyl cyclases in various diseases

Ying Gao et al. Int J Biol Macromol. 2024 Nov.

Abstract

Adenylyl cyclases (ADCYs) produce the second messengers cAMP, which is crucial for a number of cellular activities. There are ten isoforms in the mammalian ADCY family including nine transmembrane adenylyl cyclases (tmAC) and one soluble adenylyl cyclase (sAC/ADCY10). There have been numerous studies demonstrating the importance of ADCYs in the development of a wide range of diseases, including cardiovascular disease, neurological disease, liver disease, and tumors. The classification, structure and regulation of ADCYs are discussed in this overview, which is followed by an analysis of how ADCYs are involved in various disorders and how they are used as a therapeutic tool. Our objective is to get a more thorough understanding of ADCYs to aid future study and provide novel ideas for the treatment of particular diseases.

Keywords: Adenylyl cyclases; Cardiovascular disease; Liver disease; Neurological disease; Tumor.

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Conflict of interest statement

Declaration of competing interest The authors have declared that no competing interest exists.

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