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Review
. 2024 Sep 24;15(9):1168-1176.
doi: 10.5306/wjco.v15.i9.1168.

Recent advancements in understanding of biological role of homeobox C9 in human cancers

Yong Zhang  1 , Jing Li  2
Affiliations
Review

Recent advancements in understanding of biological role of homeobox C9 in human cancers

Yong Zhang et al. World J Clin Oncol. .

Abstract

Homeobox (HOX) C9, a member of the HOX family, is an important transcription factor, and it plays a significant role in various biological processes. This family of genes is highly valued for their essential roles in establishing and maintaining the body axis during embryonic development and adult tissues. Further, HOXC9 plays a central role in neuronal differentiation, angiogenesis, and adipose distribution, which are essential for the development of the nervous system, maturation of tissues and organs, and maintenance of energy balance and metabolic health. Recent research has found that abnormal HOXC9 expression is closely associated with the development and progression of various tumor types. The HOXC9 expression level can be an indicator of tumor prognosis. Therefore, elucidating the association between HOXC9 expression and its regulatory mechanisms and tumorigenesis can provide novel insights on the diagnosis and treatment of patients with cancer.

Keywords: Homeobox C9; Invasion; Malignant tumor; Molecular mechanism; Proliferation.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that there is no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Biological role of homeobox C9 in human cancer. NSCLC: Non-small-cell lung cancer.
Figure 2
Figure 2
Protein–protein interaction network of homeobox C9 based on data from the String database.
See this image and copyright information in PMC

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