Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep 9:11:1405605.
doi: 10.3389/fvets.2024.1405605. eCollection 2024.

Virus-like particles in poultry disease: an approach to effective and safe vaccination

Abdullahi Abdullahi Raji  1   2 , Paniz Zarghami Dastjerdi  1 , Abdul Rahman Omar  1   3
Affiliations
Review

Virus-like particles in poultry disease: an approach to effective and safe vaccination

Abdullahi Abdullahi Raji et al. Front Vet Sci. .

Abstract

The poultry industry, a cornerstone of global food security, faces dynamic challenges exacerbated by viral diseases. This review traces the trajectory of poultry vaccination, evolving from traditional methods to the forefront of innovation Virus-Like Particle (VLP) vaccines. Vaccination has been pivotal in disease control, but traditional vaccines exhibit some limitations. This review examines the emergence of VLPs as a game-changer in poultry vaccination. VLPs, mimicking viruses without replication, offer a safer, targeted alternative with enhanced immunogenicity. The narrative encompasses VLP design principles, production methods, immunogenicity, and efficacy against major poultry viruses. Challenges and prospects are explored, presenting VLP vaccines as a transformative technique in poultry disease control. Understanding their potential empowers industry stakeholders to navigate poultry health management with precision, promising improved welfare, reduced economic losses, and heightened food safety.

Keywords: immunogenicity; poultry; traditional vaccine; vaccine; virus-like particles.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the review was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A brief timeline of poultry vaccine evolution.
Figure 2
Figure 2
Schematic presentation of VLP vaccine production protocol, created with BioRender.com.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Birhanu MY, Osei-Amponsah R, Yeboah Obese F, Dessie T. Smallholder poultry production in the context of increasing global food prices: roles in poverty reduction and food security. Anim Front. (2023) 13:17–25. doi: 10.1093/af/vfac069, PMID: - DOI - PMC - PubMed
    1. Mottet A, Tempio G. Global poultry production: current state and future outlook and challenges. Worlds Poult Sci J. (2017) 73:245–56. doi: 10.1017/S0043933917000071 - DOI
    1. Raji AA, Omar AR. An insight into the molecular characteristics and associated pathology of chicken astroviruses. Viruses. (2022) 14:1–15. doi: 10.3390/v14040722, PMID: - DOI - PMC - PubMed
    1. Attia YA, Rahman MT, Hossain MJ, Basiouni S, Khafaga AF, Shehata AA, et al. . Poultry production and sustainability in developing countries under the COVID-19 crisis: lessons learned. Anim Open Access J MDPI. (2022) 12:644. doi: 10.3390/ani12050644, PMID: - DOI - PMC - PubMed
    1. Castro FLS, Chai L, Arango J, Owens CM, Smith PA, Reichelt S, et al. . Poultry industry paradigms: connecting the dots. J Appl Poult Res. (2023) 32:100310. doi: 10.1016/j.japr.2022.100310 - DOI

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Postdoctoral Fellowship Sponsorship provided by Tertiary Education Trust Fund (TETFund) Nigeria ref: TETF/ES/UNI/SOKOTO/TSAS/2022.

LinkOut - more resources