A review on antitumor effect of pachymic acid
- PMID: 39312302
- PMCID: PMC11419566
- DOI: 10.1097/MD.0000000000039752
A review on antitumor effect of pachymic acid
Abstract
Poria cocos, also known as Jade Ling and Songbai taro, is a dry fungus core for Wolfiporia cocos, which is parasitic on the roots of pine trees. The ancients called it "medicine of four seasons" because of its extensive effect and ability to be combined with many medicines. Pachymic acid (PA) is one of the main biological compounds of Poria cocos. Research has shown that PA has various pharmacological properties, including anti-inflammatory and antioxidant. PA has recently attracted much attention due to its anticancer properties. Researchers have found that PA showed anticancer activity by regulating apoptosis and the cell cycle in vitro and in vivo. Using PA with anticancer drugs, radiotherapy, and biomaterials could also improve the sensitivity of cancer cells and delay the progression of cancer. The purpose of this review was to summarize the anticancer mechanism of PA by referencing the published documents. A review of the collected data indicated that PA had the potential to be developed into an effective anticancer agent.
Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.
Conflict of interest statement
The author declare that they have no competing interests.
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- 2021R3132/Basic and Applied-Basic Research Project of Huaihua Science and Technology Bureau
- 2018-02/the PhD Research Startup Foundation of Hunan University of Medicine
- 22A0707/the Scientific Research Fund of Hunan Provincial Education Department
- 2021JJ30482/the Natural Science Foundation of Hunan Province of China
- 2023JJ50440/the Natural Science Foundation of Hunan Province of China
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