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Review
. 2023 Feb 9:2023:4616682.
doi: 10.1155/2023/4616682. eCollection 2023.

Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Ying Lu  1   2 , Jinjin Yang  2 , Junwen Zhu  3 , Yao Shu  2 , Xuan Zou  2 , Qiao Ruan  4 , Shuyuan Luo  2 , Yong Wang  2 , Jun Wen  4
Affiliations
Review

Advances in the Histone Acetylation Modification in the Oral Squamous Cell Carcinoma

Ying Lu et al. J Oncol. .

Abstract

Oral squamous cell carcinoma (OSCC) is one of the common malignant tumors in the head and neck, characterized by high malignancy, rapid growth and metastasis, high invasive ability, and high mortality. In recent years, surgery combined with chemotherapy or radiotherapy remains the preferred clinical treatment for OSCC, despite considerable advances in diagnostic and therapeutic techniques. Hence, new targeted therapy is urgently needed. Histone modification affects the function of massive cells through histone acetyltransferase and histone deacetylase. Accompanied by the progress of some diseases, especially tumors, these proteins often show abnormal functions, and by reversing these abnormalities with drugs or gene therapy, the cancer phenotype can even be restored to normal. As a result, they are potential drug targets. This article reviewed the role of the histone dynamic process of acetylation modifications and their associated active modifying enzymes in the pathogenesis and progress of OSCC. Moreover, we explored the value of histone acetylation modification as a potential therapeutic target and the new progress of related drugs in clinical treatment.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The dynamic process of reversible acetylation. Commonly functioning acetylation sites in oral squamous carcinoma.
See this image and copyright information in PMC

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