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Review
. 2024 Aug 29;16(17):3004.
doi: 10.3390/cancers16173004.

Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

Maria Eleonora Bizzoca  1 , Vito Carlo Alberto Caponio  1 , Lorenzo Lo Muzio  1 , Pier Paolo Claudio  2 , Antonio Cortese  3
Affiliations
Review

Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

Maria Eleonora Bizzoca et al. Cancers (Basel). .

Abstract

According to the "cancer stem cell" (CSCs) theory, tumors are a diverse and expanding group of malignant cells that originate from a small number of CSCs. Despite treatment, these cells can still become active and proliferate, which can result in distant metastasis and local recurrences. A new paradigm in cancer treatment involves targeting both CSCs and the cancer cells in a tumor. This review aims to examine the literature on methods published to overcome chemoresistance due to the presence of CSCs in head and neck cancers. The review was registered with PROSPERO (ID# CRD42024512809). After Pub Med, Scopus, and WoS database searches, 31 relevant articles on oral squamous cell carcinoma (OSCC) were selected. Compounds that increased chemosensitivity by targeting CSCs in head and neck squamous cell carcinoma (HNSCC) were divided into (1) natural products, (2) adjuvant molecules to traditional chemotherapy, and (3) CSCs targeting patient-specific fresh biopsies for functional precision medicine.

Keywords: ChemoID; cancer stem cells; functional precision medicine; head and neck squamous cell carcinoma; natural products; oral squamous cells carcinoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the selection process.
See this image and copyright information in PMC

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References

    1. Williams S.A., Anderson W.C., Santaguida M.T., Dylla S.J. Patient-derived xenografts, the cancer stem cell paradigm, and cancer pathobiology in the 21st century. Lab. Investig. 2013;93:970–982. doi: 10.1038/labinvest.2013.92. - DOI - PubMed
    1. Reya T., Morrison S.J., Clarke M.F., Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature. 2001;414:105–111. doi: 10.1038/35102167. - DOI - PubMed
    1. Rastogi P. Emergence of cancer stem cells in head and neck squamous cell carcinoma: A therapeutic insight with literature review. Dent. Res. J. 2012;9:239–244. - PMC - PubMed
    1. O’Brien C.A., Kreso A., Jamieson C.H. Cancer stem cells and self-renewal. Clin. Cancer Res. 2010;16:3113–3120. doi: 10.1158/1078-0432.CCR-09-2824. - DOI - PubMed
    1. Singh P., Augustine D., Rao R.S., Patil S., Awan K.H., Sowmya S.V., Haragannavar V.C., Prasad K. Role of cancer stem cells in head-and-neck squamous cell carcinoma-A systematic review. J. Carcinog. 2021;20:12. doi: 10.4103/jcar.JCar_14_20. - DOI - PMC - PubMed

Grants and funding

Research reported in this publication was partially supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM121334 to PPC The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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