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Review
. 2024 Sep 4;13(17):2812.
doi: 10.3390/foods13172812.

Natural Food Components as Biocompatible Carriers: A Novel Approach to Glioblastoma Drug Delivery

Arunraj Tharamelveliyil Rajendran  1 , Anoop Narayanan Vadakkepushpakath  1
Affiliations
Review

Natural Food Components as Biocompatible Carriers: A Novel Approach to Glioblastoma Drug Delivery

Arunraj Tharamelveliyil Rajendran et al. Foods. .

Abstract

Efficient drug delivery methods are crucial in modern pharmacotherapy to enhance treatment efficacy, minimize adverse effects, and improve patient compliance. Particularly in the context of glioblastoma treatment, there has been a recent surge in interest in using natural dietary components as innovative carriers for drug delivery. These food-derived carriers, known for their safety, biocompatibility, and multifunctional properties, offer significant potential in overcoming the limitations of conventional drug delivery systems. This article thoroughly overviews numerous natural dietary components, such as polysaccharides, proteins, and lipids, used as drug carriers. Their mechanisms of action, applications in different drug delivery systems, and specific benefits in targeting glioblastoma are examined. Additionally, the safety, biocompatibility, and regulatory considerations of employing food components in drug formulations are discussed, highlighting their viability and future prospects in the pharmaceutical field.

Keywords: cancer; drug delivery; food components; glioblastoma; lipids; nanocarriers; polysaccharides; proteins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of polysaccharides.
Figure 2
Figure 2
(A) Image and (B) graphical demonstration of a 3D model hydrogel composed of gelatin-chitosan (GELCH) and U87-MG cells, at the center of which an 18 % soy protein isolate hydrogel containing doxorubicin-loaded liposome was added [135].
Figure 3
Figure 3
A graphical representation of various types of lipid nanocarrier systems [183,184,185].
See this image and copyright information in PMC

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Grants and funding

The authors did not receive financial support from any organization for the submitted work.

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