Guidelines for Antibiotics Prescription in Critically Ill Patients

doi:10.5005/jp-journals-10071-24677

. 2024 Aug;28(Suppl 2):S104-S216.

doi: 10.5005/jp-journals-10071-24677. Epub 2024 Aug 10.

Guidelines for Antibiotics Prescription in Critically Ill Patients

Gopi C Khilnani¹, Pawan Tiwari², Saurabh Mittal², Atul P Kulkarni³, Dhruva Chaudhry⁴, Kapil G Zirpe⁵, Subhash K Todi⁶, Anant Mohan², Ashit Hegde⁷, Bharat G Jagiasi⁸, Bhuvana Krishna⁹, Camila Rodrigues¹⁰, Deepak Govil¹¹, Divya Pal¹¹, Jigeeshu V Divatia¹², Manju Sengar¹³, Mansi Gupta¹⁴, Mukesh Desai¹⁵, Narendra Rungta¹⁶, Parikshit S Prayag¹⁷, Pradip K Bhattacharya¹⁸, Srinivas Samavedam¹⁹, Subhal B Dixit²⁰, Sudivya Sharma¹², Susruta Bandopadhyay²¹, Venkat R Kola²², Vikas Deswal²³, Yatin Mehta¹¹, Yogendra P Singh²⁴, Sheila N Myatra¹²

Affiliations

¹ Department of Pulmonary, Critical Care and Sleep Medicine, PSRI Hospital, New Delhi, India.
² Department of Pulmonary, Critical Care and Sleep Medicine, AIIMS, New Delhi, India.
³ Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
⁴ Department of Pulmonary and Critical Care Medicine, University of Health Sciences, Rohtak, Haryana, India.
⁵ Department of Neuro Trauma Unit, Grant Medical Foundation, Pune, Maharashtra, India.
⁶ Department of Critical Care, AMRI Hospital, Kolkata, West Bengal, India.
⁷ Department of Medicine & Critical Care, P D Hinduja National Hospital, Mumbai, India.
⁸ Department of Critical Care, Kokilaben Dhirubhai Ambani Hospital, Navi Mumbai, Maharashtra, India.
⁹ Department of Critical Care Medicine, St John's Medical College and Hospital, Bengaluru, India.
¹⁰ Department of Microbiology, P D Hinduja National Hospital, Mumbai, India.
¹¹ Department of Critical Care and Anesthesia, Medanta - The Medicity, GuruGram, Haryana, India.
¹² Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹³ Department of Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹⁴ Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
¹⁵ Department of Immunology, Pediatric Hematology and Oncology Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
¹⁶ Department of Critical Care & Anaesthesiology, Rajasthan Hospital, Jaipur, India.
¹⁷ Department of Transplant Infectious Diseases, Deenanath Mangeshkar Hospital, Pune, Maharashtra, India.
¹⁸ Department of Critical Care Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
¹⁹ Department of Critical Care, Ramdev Rao Hospital, Hyderabad, Telangana, India.
²⁰ Department of Critical Care, Sanjeevan and MJM Hospital, Pune, Maharashtra, India.
²¹ Department of Critical Care, AMRI Hospitals Salt Lake, Kolkata, West Bengal, India.
²² Department of Critical Care Medicine, Yashoda Hospitals, Hyderabad, Telangana, India.
²³ Consultant, Infectious Diseases, Medanta - The Medicity, Gurugram, Haryana, India.
²⁴ Department of Critical Care, Max Super Speciality Hospital, Patparganj, New Delhi, India.

PMID: 39234229
PMCID: PMC11369928
DOI: 10.5005/jp-journals-10071-24677

Guidelines for Antibiotics Prescription in Critically Ill Patients

Gopi C Khilnani et al. Indian J Crit Care Med. 2024 Aug.

. 2024 Aug;28(Suppl 2):S104-S216.

doi: 10.5005/jp-journals-10071-24677. Epub 2024 Aug 10.

Authors

Affiliations

¹ Department of Pulmonary, Critical Care and Sleep Medicine, PSRI Hospital, New Delhi, India.
² Department of Pulmonary, Critical Care and Sleep Medicine, AIIMS, New Delhi, India.
³ Division of Critical Care Medicine, Department of Anaesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
⁴ Department of Pulmonary and Critical Care Medicine, University of Health Sciences, Rohtak, Haryana, India.
⁵ Department of Neuro Trauma Unit, Grant Medical Foundation, Pune, Maharashtra, India.
⁶ Department of Critical Care, AMRI Hospital, Kolkata, West Bengal, India.
⁷ Department of Medicine & Critical Care, P D Hinduja National Hospital, Mumbai, India.
⁸ Department of Critical Care, Kokilaben Dhirubhai Ambani Hospital, Navi Mumbai, Maharashtra, India.
⁹ Department of Critical Care Medicine, St John's Medical College and Hospital, Bengaluru, India.
¹⁰ Department of Microbiology, P D Hinduja National Hospital, Mumbai, India.
¹¹ Department of Critical Care and Anesthesia, Medanta - The Medicity, GuruGram, Haryana, India.
¹² Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹³ Department of Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
¹⁴ Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
¹⁵ Department of Immunology, Pediatric Hematology and Oncology Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
¹⁶ Department of Critical Care & Anaesthesiology, Rajasthan Hospital, Jaipur, India.
¹⁷ Department of Transplant Infectious Diseases, Deenanath Mangeshkar Hospital, Pune, Maharashtra, India.
¹⁸ Department of Critical Care Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
¹⁹ Department of Critical Care, Ramdev Rao Hospital, Hyderabad, Telangana, India.
²⁰ Department of Critical Care, Sanjeevan and MJM Hospital, Pune, Maharashtra, India.
²¹ Department of Critical Care, AMRI Hospitals Salt Lake, Kolkata, West Bengal, India.
²² Department of Critical Care Medicine, Yashoda Hospitals, Hyderabad, Telangana, India.
²³ Consultant, Infectious Diseases, Medanta - The Medicity, Gurugram, Haryana, India.
²⁴ Department of Critical Care, Max Super Speciality Hospital, Patparganj, New Delhi, India.

PMID: 39234229
PMCID: PMC11369928
DOI: 10.5005/jp-journals-10071-24677

Abstract

How to cite this article: Khilnani GC, Tiwari P, Mittal S, Kulkarni AP, Chaudhry D, Zirpe KG, et al. Guidelines for Antibiotics Prescription in Critically Ill Patients. Indian J Crit Care Med 2024;28(S2):S104-S216.

Keywords: Antibiotics; Guidelines; Infections; Intensive care unit; Prescription.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

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Unanswered Questions in the Guidelines for Antibiotic Prescription in Critically Ill Patients.
Nath SS, Nachimuthu N, Bhagyashree, Singh S. Nath SS, et al. Indian J Crit Care Med. 2024 Jul;28(7):706-707. doi: 10.5005/jp-journals-10071-24704. Indian J Crit Care Med. 2024. PMID: 38994253 Free PMC article.

References

1. Khilnani G, Zirpe K, Hadda V, Mehta Y, Madan K, Kulkarni A, et al. Guidelines for antibiotic prescription in intensive care unit. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med. 2019;23(Suppl 1):S1–S63. doi: 10.5005/jp-journals-10071-23101. - DOI - PMC - PubMed
1. Kulkarni AP, Chinnaswamy G, Desai M. Indian antimicrobial prescription guidelines in critically ill immunocompromised patients. Indian J Crit Care Med. 2018;23(S1):64–96. doi: 10.5005/jp-journals-10071-23102. - DOI - PMC - PubMed
1. Álvarez-Lerma F, Grau S. Management of antimicrobial use in the intensive care unit. Drugs. 2012;72(4):447–470. doi: 10.2165/11599520-000000000-00000. - DOI - PubMed
1. Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, et al. Beta-lactam infusion in severe sepsis (BLISS): A prospective, two-center, open-labelled randomized controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med. 2016;42(10):1535–1545. doi: 10.1007/s00134-015-4188-0. - DOI - PubMed
1. Dulhunty JM, Roberts JA, Davis JS, Webb SAR, Bellomo R, Gomersall C, et al. A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis. Am J Respir Crit Care Med. 2015;192(11):1298–1305. doi: 10.1164/rccm.201505-0857OC. - DOI - PubMed

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[1] Khilnani G, Zirpe K, Hadda V, Mehta Y, Madan K, Kulkarni A, et al. Guidelines for antibiotic prescription in intensive care unit. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med. 2019;23(Suppl 1):S1–S63. doi: 10.5005/jp-journals-10071-23101. - DOI - PMC - PubMed

[2] Khilnani G, Zirpe K, Hadda V, Mehta Y, Madan K, Kulkarni A, et al. Guidelines for antibiotic prescription in intensive care unit. Indian J Crit Care Med Peer-Rev Off Publ Indian Soc Crit Care Med. 2019;23(Suppl 1):S1–S63. doi: 10.5005/jp-journals-10071-23101. - DOI - PMC - PubMed

[3] Kulkarni AP, Chinnaswamy G, Desai M. Indian antimicrobial prescription guidelines in critically ill immunocompromised patients. Indian J Crit Care Med. 2018;23(S1):64–96. doi: 10.5005/jp-journals-10071-23102. - DOI - PMC - PubMed

[4] Kulkarni AP, Chinnaswamy G, Desai M. Indian antimicrobial prescription guidelines in critically ill immunocompromised patients. Indian J Crit Care Med. 2018;23(S1):64–96. doi: 10.5005/jp-journals-10071-23102. - DOI - PMC - PubMed

[5] Álvarez-Lerma F, Grau S. Management of antimicrobial use in the intensive care unit. Drugs. 2012;72(4):447–470. doi: 10.2165/11599520-000000000-00000. - DOI - PubMed

[6] Álvarez-Lerma F, Grau S. Management of antimicrobial use in the intensive care unit. Drugs. 2012;72(4):447–470. doi: 10.2165/11599520-000000000-00000. - DOI - PubMed

[7] Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, et al. Beta-lactam infusion in severe sepsis (BLISS): A prospective, two-center, open-labelled randomized controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med. 2016;42(10):1535–1545. doi: 10.1007/s00134-015-4188-0. - DOI - PubMed

[8] Abdul-Aziz MH, Sulaiman H, Mat-Nor MB, Rai V, Wong KK, Hasan MS, et al. Beta-lactam infusion in severe sepsis (BLISS): A prospective, two-center, open-labelled randomized controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Med. 2016;42(10):1535–1545. doi: 10.1007/s00134-015-4188-0. - DOI - PubMed

[9] Dulhunty JM, Roberts JA, Davis JS, Webb SAR, Bellomo R, Gomersall C, et al. A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis. Am J Respir Crit Care Med. 2015;192(11):1298–1305. doi: 10.1164/rccm.201505-0857OC. - DOI - PubMed

[10] Dulhunty JM, Roberts JA, Davis JS, Webb SAR, Bellomo R, Gomersall C, et al. A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis. Am J Respir Crit Care Med. 2015;192(11):1298–1305. doi: 10.1164/rccm.201505-0857OC. - DOI - PubMed

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Guidelines for Antibiotics Prescription in Critically Ill Patients

Affiliations

Guidelines for Antibiotics Prescription in Critically Ill Patients

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Affiliations

Abstract

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