Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

doi:10.1007/s12275-024-00162-9

Review

. 2024 Aug;62(8):581-590.

doi: 10.1007/s12275-024-00162-9. Epub 2024 Aug 30.

Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

Huiling Xu^#¹, Shengnan Wang^#^{1

2}, Xiaozhou Wang¹, Pu Zhang³, Qi Zheng¹, ChangXi Qi⁴, Xiaoting Liu⁴, Muzi Li¹, Yongxia Liu⁵, Jianzhu Liu^{6

7}

Affiliations

¹ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China.
² The ShangHai Hanvet Bio-Pharm Co. Ltd., Shanghai, 200135, People's Republic of China.
³ The Affiliated Taian City Central Hospital of Qingdao University, Tai`an, 271000, Shandong, People's Republic of China.
⁴ Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
⁵ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China. liuyongxia@sdau.edu.cn.
⁶ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China. liujz@sdau.edu.cn.
⁷ Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China. liujz@sdau.edu.cn.

^# Contributed equally.

PMID: 39212865
DOI: 10.1007/s12275-024-00162-9

Review

Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

Huiling Xu et al. J Microbiol. 2024 Aug.

. 2024 Aug;62(8):581-590.

doi: 10.1007/s12275-024-00162-9. Epub 2024 Aug 30.

Authors

Huiling Xu^#¹, Shengnan Wang^#^{1

2}, Xiaozhou Wang¹, Pu Zhang³, Qi Zheng¹, ChangXi Qi⁴, Xiaoting Liu⁴, Muzi Li¹, Yongxia Liu⁵, Jianzhu Liu^{6

7}

Affiliations

¹ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China.
² The ShangHai Hanvet Bio-Pharm Co. Ltd., Shanghai, 200135, People's Republic of China.
³ The Affiliated Taian City Central Hospital of Qingdao University, Tai`an, 271000, Shandong, People's Republic of China.
⁴ Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China.
⁵ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China. liuyongxia@sdau.edu.cn.
⁶ College of Veterinary Medicine, Shandong Agricultural University, Tai`an, 271018, Shandong, People's Republic of China. liujz@sdau.edu.cn.
⁷ Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, 271018, Shandong, People's Republic of China. liujz@sdau.edu.cn.

^# Contributed equally.

PMID: 39212865
DOI: 10.1007/s12275-024-00162-9

Abstract

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape.

Keywords: Bacteria; Escape; Host; Rab GTPases; Toxins; Vesicle trafficking.

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References

1. Allgood, S. C., & Neunuebel, M. R. (2018). The recycling endosome and bacterial pathogens. Cellular Microbiology, 20, e12857. - PubMed - PMC - DOI
1. Allombert, J., Jaboulay, C., Michard, C., Andréa, C., Charpentier, X., Vianney, A., & Doublet, P. (2021). Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-di-GMP signaling. Journal of Molecular Biology, 433, 166985. - PubMed - DOI
1. Alvarez-Dominguez, C., Madrazo-Toca, F., Fernandez-Prieto, L., Vandekerckhove, J., Pareja, E., Tobes, R., Gomez-Lopez, M. T., Del Cerro-Vadillo, E., Fresno, M., Leyva-Cobián, F., & Carrasco-Marín, E. (2008). Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic, 9, 325–337. - PubMed - DOI
1. Asrat, S., de Jesús, D. A., Hempstead, A. D., Ramabhadran, V., & Isberg, R. R. (2014). Bacterial pathogen manipulation of host membrane trafficking. Annual Review of Cell and Developmental Biology, 30, 79–109. - PubMed - DOI
1. Balaji, K., French, C. T., Miller, J. F., & Colicelli, J. (2014). The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection. Traffic, 15, 1206–1218. - PubMed - PMC - DOI

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[1] Allgood, S. C., & Neunuebel, M. R. (2018). The recycling endosome and bacterial pathogens. Cellular Microbiology, 20, e12857. - PubMed - PMC - DOI

[2] Allgood, S. C., & Neunuebel, M. R. (2018). The recycling endosome and bacterial pathogens. Cellular Microbiology, 20, e12857. - PubMed - PMC - DOI

[3] Allombert, J., Jaboulay, C., Michard, C., Andréa, C., Charpentier, X., Vianney, A., & Doublet, P. (2021). Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-di-GMP signaling. Journal of Molecular Biology, 433, 166985. - PubMed - DOI

[4] Allombert, J., Jaboulay, C., Michard, C., Andréa, C., Charpentier, X., Vianney, A., & Doublet, P. (2021). Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-di-GMP signaling. Journal of Molecular Biology, 433, 166985. - PubMed - DOI

[5] Alvarez-Dominguez, C., Madrazo-Toca, F., Fernandez-Prieto, L., Vandekerckhove, J., Pareja, E., Tobes, R., Gomez-Lopez, M. T., Del Cerro-Vadillo, E., Fresno, M., Leyva-Cobián, F., & Carrasco-Marín, E. (2008). Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic, 9, 325–337. - PubMed - DOI

[6] Alvarez-Dominguez, C., Madrazo-Toca, F., Fernandez-Prieto, L., Vandekerckhove, J., Pareja, E., Tobes, R., Gomez-Lopez, M. T., Del Cerro-Vadillo, E., Fresno, M., Leyva-Cobián, F., & Carrasco-Marín, E. (2008). Characterization of a Listeria monocytogenes protein interfering with Rab5a. Traffic, 9, 325–337. - PubMed - DOI

[7] Asrat, S., de Jesús, D. A., Hempstead, A. D., Ramabhadran, V., & Isberg, R. R. (2014). Bacterial pathogen manipulation of host membrane trafficking. Annual Review of Cell and Developmental Biology, 30, 79–109. - PubMed - DOI

[8] Asrat, S., de Jesús, D. A., Hempstead, A. D., Ramabhadran, V., & Isberg, R. R. (2014). Bacterial pathogen manipulation of host membrane trafficking. Annual Review of Cell and Developmental Biology, 30, 79–109. - PubMed - DOI

[9] Balaji, K., French, C. T., Miller, J. F., & Colicelli, J. (2014). The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection. Traffic, 15, 1206–1218. - PubMed - PMC - DOI

[10] Balaji, K., French, C. T., Miller, J. F., & Colicelli, J. (2014). The RAB5-GEF function of RIN1 regulates multiple steps during Listeria monocytogenes infection. Traffic, 15, 1206–1218. - PubMed - PMC - DOI

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Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

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Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

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