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Review
. 2024 Oct 22;98(10):e0114824.
doi: 10.1128/jvi.01148-24. Epub 2024 Aug 30.

Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions

Ian J Groves  1   2 , Christine M O'Connor  1   2
Affiliations
Review

Loopy virus or controlled contortionist? 3D regulation of HCMV gene expression by CTCF-driven chromatin interactions

Ian J Groves et al. J Virol. .

Abstract

Three-dimensional chromatin control of eukaryotic transcription is pivotal for regulating gene expression. This additional layer of epigenetic regulation is also utilized by DNA viruses, including herpesviruses. Dynamic, spatial genomic organization often involves looping of chromatin anchored by host-encoded CCCTC-binding factor (CTCF) and other factors, which control crosstalk between promoters and enhancers. Herein, we review the contribution of CTCF-mediated looping in regulating transcription during herpesvirus infection, with a specific focus on the betaherpesvirus, human cytomegalovirus (HCMV).

Keywords: CMV; CTCF; HCMV; HHV; chromatin; cytomegalovirus; epigenetics; herpesvirus.

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Conflict of interest statement

The authors declare no conflict of interest.

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