Inflammatory aspects of Alzheimer's disease
- PMID: 39196440
- DOI: 10.1007/s00401-024-02790-2
Inflammatory aspects of Alzheimer's disease
Abstract
Alzheimer´s disease (AD) stands out as the most common chronic neurodegenerative disorder. AD is characterized by progressive cognitive decline and memory loss, with neurodegeneration as its primary pathological feature. The role of neuroinflammation in the disease course has become a focus of intense research. While microglia, the brain's resident macrophages, have been pivotal to study central immune inflammation, recent evidence underscores the contributions of other cellular entities to the neuroinflammatory process. In this article, we review the inflammatory role of microglia and astrocytes, focusing on their interactions with AD's core pathologies, amyloid beta deposition, and tau tangle formation. Additionally, we also discuss how different modes of regulated cell death in AD may impact the chronic neuroinflammatory environment. This review aims to highlight the evolving landscape of neuroinflammatory research in AD and underscores the importance of considering multiple cellular contributors when developing new therapeutic strategies.
Keywords: Activation; Alzheimer’s disease; Cytokine; Immune mediator; Innate immunity; Neurodegeneration; Neuroinflammation.
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Cited by
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Regulated cell death in neurodegeneration: pathways and therapeutic horizons.Acta Neuropathol. 2024 Sep 24;148(1):47. doi: 10.1007/s00401-024-02808-9. Acta Neuropathol. 2024. PMID: 39317858 No abstract available.
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