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. 2024 Aug 3;46(8):8512-8525.
doi: 10.3390/cimb46080501.

Connecting the Dots: FGF21 as a Potential Link between Obesity and Cardiovascular Health in Acute Coronary Syndrome Patients

Cristina Elena Negroiu  1   2 , Anca-Lelia Riza  3   4 , Ioana Streață  3   4 , Iulia Tudorașcu  1 , Cristina Maria Beznă  1   5 , Adrian Ionuț Ungureanu  2   5 , Suzana Dănoiu  1
Affiliations

Connecting the Dots: FGF21 as a Potential Link between Obesity and Cardiovascular Health in Acute Coronary Syndrome Patients

Cristina Elena Negroiu et al. Curr Issues Mol Biol. .

Abstract

Fibroblast growth factor 21 (FGF21) is a hormone involved in regulating the metabolism, energy balance, and glucose homeostasis, with new studies demonstrating its beneficial effects on the heart. This study investigated the relationship between FGF21 levels and clinical, biochemical, and echocardiographic parameters in patients with acute coronary syndromes (ACSs). This study included 80 patients diagnosed with ACS between May and July 2023, categorized into four groups based on body mass index (BMI): Group 1 (BMI 18.5-24.9 kg/m2), Group 2 (BMI 25-29.9 kg/m2), Group 3 (BMI 30-34.9 kg/m2), and Group 4 (BMI ≥ 35 kg/m2). Serum FGF21 levels were measured by ELISA (Abclonal Catalog NO.: RK00084). Serum FGF21 levels were quantifiable in 55 samples (mean ± SD: 342.42 ± 430.17 pg/mL). Group-specific mean FGF21 levels were 238.98 pg/mL ± SD in Group 1 (n = 14), 296.78 pg/mL ± SD in Group 2 (n = 13), 373.77 pg/mL ± SD in Group 3 (n = 12), and 449.94 pg/mL ± SD in Group 4 (n = 16), with no statistically significant differences between groups (p = 0.47). Based on ACS diagnoses, mean FGF21 levels were 245.72 pg/mL for STEMI (n = 21), 257.89 pg/mL for NSTEMI (n = 9), and 456.28 pg/mL for unstable angina (n = 25), with no significant differences observed between these diagnostic categories. Significant correlations were identified between FGF21 levels and BMI, diastolic blood pressure, and serum chloride. Regression analyses revealed correlations with uric acid, chloride, and creatinine kinase MB. This study highlights the complex interplay between FGF21, BMI, and acute coronary syndromes. While no significant differences were found in FGF21 levels between the different BMI and ACS diagnostic groups, correlations with clinical and biochemical parameters suggest a multifaceted role of FGF21 in cardiovascular health. Further research with a larger sample size is warranted to elucidate these relationships.

Keywords: FGF21; myocardial infarction; obesity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Distribution of Admission Diagnoses across BMI Groups in Study Patients.
Figure 2
Figure 2
Parameters with significant differences among the study groups: Group 1 includes 20 patients with a BMI between 18.5 and 24.9 kg/m2, (2) Group 2 includes 20 patients with a BMI between 25 and 29.9 kg/m2, (3) Group 3 includes 20 patients with a BMI between 30 and 34.9 kg/m2, and (4) Group 4 includes 20 patients with a BMI greater than 35 kg/m2. The panels show the comparison across groups for (A) weight, (B) waist circumference, (C) BMI, (D) interventricular septum thickness, (E) posterior wall thickness of the left ventricle, (F) inferior vena cava diameter, (G) aspartate aminotransferase levels, (H) triglycerides levels, (I) leukocytes and (J) erythrocyte sedimentation rate. Post hoc analysis was conducted to identify significant differences between the groups. Statistically significant differences (p < 0.05) are indicated. Error bars represent the standard deviation (SD).
Figure 2
Figure 2
Parameters with significant differences among the study groups: Group 1 includes 20 patients with a BMI between 18.5 and 24.9 kg/m2, (2) Group 2 includes 20 patients with a BMI between 25 and 29.9 kg/m2, (3) Group 3 includes 20 patients with a BMI between 30 and 34.9 kg/m2, and (4) Group 4 includes 20 patients with a BMI greater than 35 kg/m2. The panels show the comparison across groups for (A) weight, (B) waist circumference, (C) BMI, (D) interventricular septum thickness, (E) posterior wall thickness of the left ventricle, (F) inferior vena cava diameter, (G) aspartate aminotransferase levels, (H) triglycerides levels, (I) leukocytes and (J) erythrocyte sedimentation rate. Post hoc analysis was conducted to identify significant differences between the groups. Statistically significant differences (p < 0.05) are indicated. Error bars represent the standard deviation (SD).
Figure 3
Figure 3
The FGF21 values in pg/mL in the conducted study.
See this image and copyright information in PMC

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References

    1. Sattar N., Neeland I.J., McGuire D.K. Obesity and Cardiovascular Disease: A New Dawn. Circulation. 2024;149:1621–1623. doi: 10.1161/CIRCULATIONAHA.123.065485. - DOI - PubMed
    1. Bulnes J.F., González L., Velásquez L., Orellana M.P., Venturelli P.M., Martínez G. Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome. Front. Cardiovasc. Med. 2024;11:1356023. doi: 10.3389/fcvm.2024.1356023. - DOI - PMC - PubMed
    1. Timmis A., Vardas P., Townsend N., Torbica A., Katus H., De Smedt D., Gale C.P., Maggioni A.P., Petersen S.E., Huculeci R., et al. European Society of Cardiology: Cardiovascular disease statistics 2021. Eur. Heart J. 2022;43:716–799. doi: 10.1093/eurheartj/ehab892. - DOI - PubMed
    1. Nishimura T., Nakatake Y., Konishi M., Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim. Biophys. Acta. 2000;1492:203–206. doi: 10.1016/S0167-4781(00)00067-1. - DOI - PubMed
    1. Salminen A., Kaarniranta K., Kauppinen A. Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity. Cell Signal. 2017;40:10–21. doi: 10.1016/j.cellsig.2017.08.009. - DOI - PubMed

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