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Review
. 2024 Aug 10;13(8):605.
doi: 10.3390/biology13080605.

Advances in Regenerative and Reconstructive Medicine in the Prevention and Treatment of Bone Infections

Leticia Ramos Dantas  1 , Gabriel Burato Ortis  1 , Paula Hansen Suss  1 , Felipe Francisco Tuon  1
Affiliations
Review

Advances in Regenerative and Reconstructive Medicine in the Prevention and Treatment of Bone Infections

Leticia Ramos Dantas et al. Biology (Basel). .

Abstract

Reconstructive and regenerative medicine are critical disciplines dedicated to restoring tissues and organs affected by injury, disease, or congenital anomalies. These fields rely on biomaterials like synthetic polymers, metals, ceramics, and biological tissues to create substitutes that integrate seamlessly with the body. Personalized implants and prosthetics, designed using advanced imaging and computer-assisted techniques, ensure optimal functionality and fit. Regenerative medicine focuses on stimulating natural healing mechanisms through cellular therapies and biomaterial scaffolds, enhancing tissue regeneration. In bone repair, addressing defects requires advanced solutions such as bone grafts, essential in medical and dental practices worldwide. Bovine bone scaffolds offer advantages over autogenous grafts, reducing surgical risks and costs. Incorporating antimicrobial properties into bone substitutes, particularly with metals like zinc, copper, and silver, shows promise in preventing infections associated with graft procedures. Silver nanoparticles exhibit robust antimicrobial efficacy, while zinc nanoparticles aid in infection prevention and support bone healing; 3D printing technology facilitates the production of customized implants and scaffolds, revolutionizing treatment approaches across medical disciplines. In this review, we discuss the primary biomaterials and their association with antimicrobial agents.

Keywords: bacteria; biofilm; bone; impregnation; nanotechnology; silver.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A diagram demonstrating multiple options for doping bone grafts or polymers for 3D printing using metal nanoparticles or antibiotics in bone reconstruction.
Figure 2
Figure 2
Silver nanoparticles on bone surface used for orthopedic graft.
Figure 3
Figure 3
Antibiotic-impregnated PLA models with Staphylococcus aureus test.
Figure 4
Figure 4
Implants with PLA impregnated with antibiotics tested during surgery for hip replacement.
See this image and copyright information in PMC

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References

    1. Singh A.K., Sundram S., Malviya R. Human-derived Biomaterials for Biomedical and Tissue Engineering Applications. Curr. Pharm. Des. 2023;29:584–603. doi: 10.2174/1381612829666230320103412. - DOI - PubMed
    1. Elgali I., Omar O., Dahlin C., Thomsen P. Guided bone regeneration: Materials and biological mechanisms revisited. Eur. J. Oral. Sci. 2017;125:315–337. doi: 10.1111/eos.12364. - DOI - PMC - PubMed
    1. Aimar A., Palermo A., Innocenti B. The Role of 3D Printing in Medical Applications: A State of the Art. J. Healthc. Eng. 2019;2019:5340616. doi: 10.1155/2019/5340616. - DOI - PMC - PubMed
    1. Edgar L., Pu T., Porter B., Aziz J.M., La Pointe C., Asthana A., Orlando G. Regenerative medicine, organ bioengineering and transplantation. Br. J. Surg. 2020;107:793–800. doi: 10.1002/bjs.11686. - DOI - PubMed
    1. Hochuli A.H.D., Senegaglia A.C., Selenko A.H., Fracaro L., Brofman P.R.S. Dental Pulp from Human Exfoliated Deciduous Teeth-derived Stromal Cells Demonstrated Neuronal Potential: In Vivo and In Vitro Studies. Curr. Stem Cell Res. Ther. 2021;16:495–506. doi: 10.2174/1574888X16666210215160402. - DOI - PubMed

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