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. 2024 Aug 13:15:1433050.
doi: 10.3389/fimmu.2024.1433050. eCollection 2024.

Application of hydrogels in cancer immunotherapy: a bibliometric analysis

Xiang Liu #  1 , Qiang Zhou #  2 , Yue Yang  1 , Erhua Chen  1
Affiliations

Application of hydrogels in cancer immunotherapy: a bibliometric analysis

Xiang Liu et al. Front Immunol. .

Abstract

Background: Cancer immunotherapy has made significant progress in recent years, with numerous studies worldwide. Immunotherapy has had a transformative impact on oncology and autoimmune diseases. In the biomedical arena, hydrogels with good properties are widely used in cancer immunotherapy. Our study used bibliometrics to analyze the changing trends in using hydrogels for cancer immunotherapy.

Methods: From 2013 to 2023, a systematic search was conducted in the Web of Science Core Collection database to identify reviews and articles discussing the applications of hydrogels in cancer immunotherapy. The software CiteSpace was used to visually perform the bibliometric analysis in terms of research trends, countries, institutions, authors, journals, and keywords. Individual authors' productivity was assessed with the Lotka's law. The most relevant publication sources were identified by Bradford's law.

Results: A total of 422 English-language publications related to hydrogels in cancer immunotherapy were collected. The number of annual publications increased rapidly after 2021 and remained constant for the past two years. China published the most articles in this field. The institution with the maximum number of published articles was the Chinese Academy of Sciences in China. Chen. Q was the most prolific author, and Liu. Z was the second most published author. In terms of journal contributions, the journal "Biomaterials" had the highest number of publications (n = 30). Biomaterials, Advanced Functional Materials and Journal of Controlled Release were the most influential journals. Keyword analysis revealed that cancer immunotherapy, drug delivery, immunogenic cell death, tumor microenvironment, injectable hydrogels, and immune checkpoint blockade were the primary research hotspots. In recent 3 years, adoptive T-cell therapy, black phosphorus, cell capture, adaptive cell therapy, tumor microenvironment, photodynamic therapy, and sustained release were the research hotspots in this field. Our study summarizes the objective of hydrogels in cancer immunotherapy in recent years, providing a reference for potential researchers in related field.

Conclusion: This bibliometric analysis shows the progress and trend of research on hydrogels in cancer immunotherapy. This study provides a significant avenue for future investigation into current concerns and trends in research within this field.

Keywords: Citespace; bibliometrics; cancer; cancer immunotherapy; hydrogels.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Global publication output and future publication trends of hydrogels in cancer immunotherapy from 2013 to 2023.
Figure 2
Figure 2
The co-occurrence map of countries.
Figure 3
Figure 3
The co-occurrence map of research institutions.
Figure 4
Figure 4
The co-occurrence map of authors.
Figure 5
Figure 5
Author productivity using Lotkaw’s law. Solid black line indicates the distribution of published articles according to Lotkaw’s law. The dotted line indicates the publication on subject matter.
Figure 6
Figure 6
The dual-map overlay of journals on research of hydrogels in cancer immunotherapy.
Figure 7
Figure 7
Bradford’s law applied to the set of publications.
Figure 8
Figure 8
Visualization map of the keyword co-occurrence network.
Figure 9
Figure 9
Cluster analysis of keywords.
Figure 10
Figure 10
Time zone view of keywords.
See this image and copyright information in PMC

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