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Case Reports
. 2024 Jul 27;16(7):e65485.
doi: 10.7759/cureus.65485. eCollection 2024 Jul.

Parotid Enlargement as a Rare First Site of Manifestation in Extramedullary Acute Lymphoblastic Leukemia: A Case Report

Nursyamimi Mohmad Zaki  1 , Azwan Halim Abdul Wahab  1
Affiliations
Case Reports

Parotid Enlargement as a Rare First Site of Manifestation in Extramedullary Acute Lymphoblastic Leukemia: A Case Report

Nursyamimi Mohmad Zaki et al. Cureus. .

Abstract

Parotid neoplasm in children is very rare, and most of these tumors are benign. Parotid enlargement in children is usually caused by infection or inflammation. We report a case of a 12-year-old boy who presented with the initial manifestation of bilateral parotid enlargement. He complained of two weeks of parotid swelling, during which the tumor gradually increased in size as he battled a monthlong on-and-off fever. An intravenous antibiotic was administered, as the first diagnosis was infection. Imaging studies of the swelling displayed features of infection, which was not resolved by the antibiotic. Fine-needle aspiration cytology was initially planned to establish a diagnosis. However, due to other findings in the clinical examination, such as bilateral scrotal swelling with abnormal blood work, the child was referred to other specialists for further assessment. Eventually, he was diagnosed with B-cell acute lymphoblastic leukemia by a hematology team.

Keywords: acute lymphoblastic leukemia; acute parotitis; extramedullary leukemia; fine-needle aspiration cytology; parotid tumor.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. A CECT of the neck showed homogenously enhanced bilateral parotid glands and appeared bulky, but no focal hypodense area with peripheral enhancement was visible to suggest collection.
(A) A CECT of the neck sagittal cut with asterisks showed bilateral parotid masses; (B) CECT of the neck axial cut with asterisks showed bilateral parotid masses. CECT: contrast-enhanced computed tomography.
See this image and copyright information in PMC

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References

    1. Bilateral parotidomegaly as an initial manifestation of acute lymphoblastic leukemia in a child: a case report and review of literature. Sneha LM, Subbiah KS, Scott JX, Rajendiran A. Natl J Maxillofac Surg. 2017;8:55–57. - PMC - PubMed
    1. Acute lymphoblastic leukaemia. Inaba H, Greaves M, Mullighan CG. Lancet. 2013;381:1943–1955. - PMC - PubMed
    1. Acute lymphoblastic leukemia in children. Hunger SP, Mullighan CG. N Engl J Med. 2015;373:1541–1552. - PubMed
    1. Acute viral and bacterial infections of the salivary glands. McQuone SJ. Otolaryngol Clin North Am. 1999;32:793–811. - PubMed
    1. Pediatric parotid masses. Orvidas LJ, Kasperbauer JL, Lewis JE, Olsen KD, Lesnick TG. Arch Otolaryngol Head Neck Surg. 2000;126:177–184. - PubMed

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