Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

doi:10.1007/s10865-024-00515-0

. 2024 Dec;47(6):1040-1051.

doi: 10.1007/s10865-024-00515-0. Epub 2024 Aug 23.

Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

Zhou Jin¹, Xuejian Liu¹, Haonan Guo², Sixuan Chen¹, Xianghe Zhu¹, Sipei Pan³, Yili Wu⁴

Affiliations

¹ Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
² Department of Sociology, Faculty of Social Science, University of Macau, Avenida da Universidade, Taipa, Macau, China.
³ Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
⁴ Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wuyili@wmu.edu.cn.

PMID: 39179728
DOI: 10.1007/s10865-024-00515-0

Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

Zhou Jin et al. J Behav Med. 2024 Dec.

. 2024 Dec;47(6):1040-1051.

doi: 10.1007/s10865-024-00515-0. Epub 2024 Aug 23.

Authors

Zhou Jin¹, Xuejian Liu¹, Haonan Guo², Sixuan Chen¹, Xianghe Zhu¹, Sipei Pan³, Yili Wu⁴

Affiliations

¹ Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
² Department of Sociology, Faculty of Social Science, University of Macau, Avenida da Universidade, Taipa, Macau, China.
³ Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
⁴ Zhejiang Provincial Clinical Research Center for Mental Disorders, Wenzhou Key Laboratory of Basic and Translational Research for Mental Disorders, School of Mental Health and The Affiliated Wenzhou Kangning Hospital, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. wuyili@wmu.edu.cn.

PMID: 39179728
DOI: 10.1007/s10865-024-00515-0

Abstract

Telomere length, a biomarker of human aging, is related to adverse health outcomes. Growing evidence indicates that oxidative stress and inflammation contributes to telomere shortening, whereas social support may protect from telomere shortening. Despite sex differences in telomere length and social support, little is known about whether there are sex differences in the relationship between oxidative stress/inflammation and telomere length, and sex-specific moderating roles of social support in older adults. Using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002, this study assessed whether the associations between oxidative stress/inflammation and telomere length vary with sex and explored social support as a moderator in these associations among 2289 older adults. Oxidative stress was measured based on serum Gamma-glutamyl transferase (GGT), and inflammation was measured based on C-reactive protein (CRP). After adjusting for the covariates, GGT was significantly associated with telomere length in females only (β = - 0.037, 95% CI = - 0.070, - 0.005), while CRP was associated with telomere length in males only (β = - 0.019, 95% CI = - 0.035, - 0.002). Moreover, high social support mitigated the negative association between GGT and telomere length, which was more evident in females. Furthermore, social support moderated the association between CRP and telomere length in males aged 70 and above. Our findings indicated that biological mechanisms related to telomere length may vary with sex, while social support plays a sex-specific moderating role.

Keywords: Inflammation; Moderation; NHANES; Oxidative stress; Sex difference; Social support; Telomere length.

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References

1. Alonso-Alvarez, C., Bertrand, S., Faivre, B., Chastel, O., & Sorci, G. (2007). Testosterone and oxidative stress: The oxidation handicap hypothesis. Proceedings of the Royal Society B: Biological Sciences, 274, 819–825. https://doi.org/10.1098/rspb.2006.3764 - DOI
1. Antonucci, T. C., & Akiyama, H. (1987). An examination of sex differences in social support among older men and women. Sex Roles, 17, 737–749. https://doi.org/10.1007/BF00287685 - DOI
1. Armstrong, E., & Boonekamp, J. (2023). Does oxidative stress shorten telomeres in vivo? A Meta-Analysis. Ageing Research Reviews, 85, 101854. https://doi.org/10.1016/j.arr.2023.101854 - DOI - PubMed
1. Ashe, K. M., & Lapane, K. L. (2017). Food insecurity and obesity: Exploring the role of social support. Journal of Women’s Health, 27, 651–658. https://doi.org/10.1089/jwh.2017.6454 - DOI - PubMed
1. Babizhayev, M. A., Savel’yeva, E. L., Moskvina, S. N., & Yegorov, Y. E. (2011). Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. American Journal of Therapeutics, 18, e209-226. https://doi.org/10.1097/MJT.0b013e3181cf8ebb - DOI - PubMed

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[1] Alonso-Alvarez, C., Bertrand, S., Faivre, B., Chastel, O., & Sorci, G. (2007). Testosterone and oxidative stress: The oxidation handicap hypothesis. Proceedings of the Royal Society B: Biological Sciences, 274, 819–825. https://doi.org/10.1098/rspb.2006.3764 - DOI

[2] Alonso-Alvarez, C., Bertrand, S., Faivre, B., Chastel, O., & Sorci, G. (2007). Testosterone and oxidative stress: The oxidation handicap hypothesis. Proceedings of the Royal Society B: Biological Sciences, 274, 819–825. https://doi.org/10.1098/rspb.2006.3764 - DOI

[3] Antonucci, T. C., & Akiyama, H. (1987). An examination of sex differences in social support among older men and women. Sex Roles, 17, 737–749. https://doi.org/10.1007/BF00287685 - DOI

[4] Antonucci, T. C., & Akiyama, H. (1987). An examination of sex differences in social support among older men and women. Sex Roles, 17, 737–749. https://doi.org/10.1007/BF00287685 - DOI

[5] Armstrong, E., & Boonekamp, J. (2023). Does oxidative stress shorten telomeres in vivo? A Meta-Analysis. Ageing Research Reviews, 85, 101854. https://doi.org/10.1016/j.arr.2023.101854 - DOI - PubMed

[6] Armstrong, E., & Boonekamp, J. (2023). Does oxidative stress shorten telomeres in vivo? A Meta-Analysis. Ageing Research Reviews, 85, 101854. https://doi.org/10.1016/j.arr.2023.101854 - DOI - PubMed

[7] Ashe, K. M., & Lapane, K. L. (2017). Food insecurity and obesity: Exploring the role of social support. Journal of Women’s Health, 27, 651–658. https://doi.org/10.1089/jwh.2017.6454 - DOI - PubMed

[8] Ashe, K. M., & Lapane, K. L. (2017). Food insecurity and obesity: Exploring the role of social support. Journal of Women’s Health, 27, 651–658. https://doi.org/10.1089/jwh.2017.6454 - DOI - PubMed

[9] Babizhayev, M. A., Savel’yeva, E. L., Moskvina, S. N., & Yegorov, Y. E. (2011). Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. American Journal of Therapeutics, 18, e209-226. https://doi.org/10.1097/MJT.0b013e3181cf8ebb - DOI - PubMed

[10] Babizhayev, M. A., Savel’yeva, E. L., Moskvina, S. N., & Yegorov, Y. E. (2011). Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement associated with smoking behavior. American Journal of Therapeutics, 18, e209-226. https://doi.org/10.1097/MJT.0b013e3181cf8ebb - DOI - PubMed

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Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

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Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

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