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Review
. 2024 Sep 3;36(9):1914-1944.
doi: 10.1016/j.cmet.2024.07.025. Epub 2024 Aug 22.

A nutrigeroscience approach: Dietary macronutrients and cellular senescence

Mariah F Calubag  1 , Paul D Robbins  2 , Dudley W Lamming  3
Affiliations
Review

A nutrigeroscience approach: Dietary macronutrients and cellular senescence

Mariah F Calubag et al. Cell Metab. .

Abstract

Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is one of the hallmarks of aging. Senescence and the senescence-associated secretory phenotype (SASP)-a heterogeneous set of secreted factors that disrupt tissue homeostasis and promote the accumulation of senescent cells-reprogram metabolism and can lead to metabolic dysfunction. Dietary interventions have long been studied as methods to combat age-associated metabolic dysfunction, promote health, and increase lifespan. A growing body of literature suggests that senescence is responsive to diet, both to calories and specific dietary macronutrients, and that the metabolic benefits of dietary interventions may arise in part through reducing senescence. Here, we review what is currently known about dietary macronutrients' effect on senescence and the SASP, the nutrient-responsive molecular mechanisms that may mediate these effects, and the potential for these findings to inform the development of a nutrigeroscience approach to healthy aging.

Keywords: branched-chain amino acids; cellular senescence; healthspan; macronutrients; nutrigeroscience; protein; senescence-associated secretory phenotype.

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Conflict of interest statement

Declaration of interests D.W.L. has received funding from and is a scientific advisory board member of Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases. P.D.R. is a co-founder of Itasca Therapeutics, a new start-up developing novel senotherapeutics to extend human healthspan.

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References

    1. Anderson LA, Goodman RA, Holtzman D, Posner SF, and Northridge ME (2012). Aging in the United States: opportunities and challenges for public health. Am J Public Health 102, 393–395. 10.2105/AJPH.2011.300617. - DOI - PMC - PubMed
    1. Martin GM (2017). Geroscience: Addressing the mismatch between its exciting research opportunities, its economic imperative and its current funding crisis. Exp Gerontol 94, 46–51. 10.1016/j.exger.2016.11.008. - DOI - PMC - PubMed
    1. Bellantuono I, de Cabo R, Ehninger D, Di Germanio C, Lawrie A, Miller J, Mitchell SJ, Navas-Enamorado I, Potter PK, Tchkonia T, et al. (2020). A toolbox for the longitudinal assessment of healthspan in aging mice. Nature protocols 15, 540–574. 10.1038/s41596-019-0256-1. - DOI - PMC - PubMed
    1. Campisi J, and d'Adda di Fagagna F (2007). Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8, 729–740. 10.1038/nrm2233. - DOI - PubMed
    1. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, and Kroemer G (2013). The hallmarks of aging. Cell 153, 1194–1217. 10.1016/j.cell.2013.05.039. - DOI - PMC - PubMed

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