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Review
. 2024 Nov 15:141:112928.
doi: 10.1016/j.intimp.2024.112928. Epub 2024 Aug 18.

Advances in the mechanism of action of short-chain fatty acids in psoriasis

Qin Zhang  1 , Linna Zhao  2 , Yu Li  3 , Siyao Wang  3 , Guiling Lu  4 , Hongmei Wang  5
Affiliations
Review

Advances in the mechanism of action of short-chain fatty acids in psoriasis

Qin Zhang et al. Int Immunopharmacol. .

Abstract

Psoriasis is a prevalent chronic inflammatory and immunological disorder. Its lesions are present as scaly erythema or plaques. Disruptions in the body's immune system play a significant role in developing psoriasis. Recent evidence suggests a potential role of the gut microbiome in autoimmune diseases. Short-chain fatty acids (SCFAs) are the primary metabolites created by gut microbes and play a crucial fuction in autoimmunity. SCFAs act on various cells by mediating signaling to participate in host physiological and pathological processes. These processes encompass body metabolism, maintenance of intestinal barrier function, and immune system modulation. SCFAs can regulate immune cells to enhance the body's immune function, potentially influencing the prevention and treatment of psoriasis. However, the mechanisms underlying the role of SCFAs in psoriasis remain incompletely understood. This paper examines the relationship between SCFAs and psoriasis, elucidating how SCFAs influence the immune system, inflammatory response, and gut barrier in psoriasis. According to the study, in psoriasis, SCFAs have been shown to regulate neutrophils, macrophages, and dendritic cells in the adaptive immune system, as well as T and B cells in the innate immune system. Additionally, we explore the role of SCFAs in psoriasis by maintaining intestinal barrier function, restoring intestinal ecological homeostasis, and investigating the potential therapeutic benefits of SCFAs for psoriasis.

Keywords: Immunity; Inflammation; Intestinal barrier; Psoriasis; SCFAs.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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