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Review
. 2024 Aug 19.
doi: 10.1007/s11886-024-02117-3. Online ahead of print.

Beyond the Heartbeat: Single-Cell Omics Redefining Cardiovascular Research

Sabine Seeler #  1   2 , Kristjan Arnarsson #  1   2 , Martina Dreßen  1   2 , Markus Krane  1   2   3   4 , Stefanie A Doppler  5   6
Affiliations
Review

Beyond the Heartbeat: Single-Cell Omics Redefining Cardiovascular Research

Sabine Seeler et al. Curr Cardiol Rep. .

Abstract

Purpose of review: This review aims to explore recent advances in single-cell omics techniques as applied to various regions of the human heart, illuminating cellular diversity, regulatory networks, and disease mechanisms. We examine the contributions of single-cell transcriptomics, genomics, proteomics, epigenomics, and spatial transcriptomics in unraveling the complexity of cardiac tissues.

Recent findings: Recent strides in single-cell omics technologies have revolutionized our understanding of the heart's cellular composition, cell type heterogeneity, and molecular dynamics. These advancements have elucidated pathological conditions as well as the cellular landscape in heart development. We highlight emerging applications of integrated single-cell omics, particularly for cardiac regeneration, disease modeling, and precision medicine, and emphasize the transformative potential of these technologies to advance cardiovascular research and clinical practice.

Keywords: Cardiovascular disease; Integrative multi-omics; Single cell epigenomics; Single cell transcriptomics; Spatial transcriptomics.

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References

    1. Miranda AMA, Janbandhu V, Maatz H, Kanemaru K, Cranley J, Teichmann SA, et al. Single-cell transcriptomics for the assessment of cardiac disease. Nat Rev Cardiol. 2023;20(5):289–308. https://doi.org/10.1038/s41569-022-00805-7 . - DOI - PubMed
    1. Cao J, O’Day DR, Pliner HA, Kingsley PD, Deng M, Daza RM, et al. A human cell atlas of fetal gene expression. Science. 2020;370(6518):eaba7721. https://doi.org/10.1126/science.aba7721 . - DOI - PubMed - PMC
    1. Asp M, Giacomello S, Larsson L, Wu C, Fürth D, Qian X, et al. A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart. Cell. 2019;179(7):1647-1660.e19. https://doi.org/10.1016/j.cell.2019.11.025 . - DOI - PubMed
    1. Cui Y, Zheng Y, Liu X, Yan L, Fan X, Yong J, et al. Single-cell transcriptome analysis maps the developmental track of the human heart. Cell Rep. 2019;26(7):1934-1950.e5. https://doi.org/10.1016/j.celrep.2019.01.079 . - DOI - PubMed
    1. Suryawanshi H, Clancy R, Morozov P, Halushka MK, Buyon JP, Tuschl T. Cell atlas of the foetal human heart and implications for autoimmune-mediated congenital heart block. Cardiovasc Res. 2019;116(8):1446–57. https://doi.org/10.1093/cvr/cvz257 . - DOI - PMC

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