Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Aug 6.
doi: 10.1007/s00210-024-03342-x. Online ahead of print.

Monoterpenoid synergy: a new frontier in biological applications

Md Zamshed Alam Begh  1 , Jishan Khan  2 , Md Al Amin  3 , Sherouk Hussein Sweilam  4   5 , G Dharmamoorthy  6 , Jeetendra Kumar Gupta  7 , J Sangeetha  8 , R Lokeshvar  9 , Mohamed H Nafady  10 , Irfan Ahmad  11 , Mohammed Ali Alshehri  12 , Talha Bin Emran  13
Affiliations
Review

Monoterpenoid synergy: a new frontier in biological applications

Md Zamshed Alam Begh et al. Naunyn Schmiedebergs Arch Pharmacol. .

Abstract

Monoterpenoids, compounds found in various organisms, have diverse applications in various industries. Their effectiveness is influenced by the oil's chemical composition, which in turn is influenced by plant genotype, environmental conditions, cultivation practices, and plant development stage. They are used in various industries due to their distinctive odor and taste, serving as ingredients, additives, insecticides, and repellents. These compounds have synergistic properties, resulting in superior combined effects over discrete ones, potentially beneficial for various health purposes. Many experimental studies have investigated their interactions with other ingredients and their antibacterial, insecticidal, antifungal, anticancer, anti-inflammatory, and antioxidant properties. This review discusses potential synergistic interactions between monoterpenoids and other compounds, their sources, and biological functions. It also emphasizes the urgent need for more research on their bioavailability and toxicity, underlining the importance and relevance of this comprehensive study in the current scientific landscape.

Keywords: Bioactivities; Essential oils; Monoterpenoids; Synergistic effect; Toxicological profile.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Adil M, Baig MH, Rupasinghe HPV (2019) Impact of citral and phloretin, alone and in combination, on major virulence traits of Streptococcus pyogenes. Molecules 24:4237 - PubMed - PMC - DOI
    1. Aeschbach R, Löliger J, Scott BC et al (1994) Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol 32:31–36 - PubMed - DOI
    1. Ahn S, Lee JY, Choi SM et al (2020) A mixture of tocopherol acetate and L-menthol synergistically promotes hair growth in C57BL/6 mice. Pharmaceutics 12:1234 - PubMed - PMC - DOI
    1. Ait-Ouazzou A, Espina L, Gelaw TK et al (2013) New insights in mechanisms of bacterial inactivation by carvacrol. J Appl Microbiol 114:173–185 - PubMed - DOI
    1. Al-Bayati FA (2009) Isolation and identification of antimicrobial compound from Mentha longifolia L. leaves grown wild in Iraq. Ann Clin Microbiol Antimicrob 8:1–6 - DOI

LinkOut - more resources