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Review
. 2024 Sep;602(17):4097-4110.
doi: 10.1113/JP286313. Epub 2024 Jul 31.

Fibroblast growth factor homologous factors: canonical and non-canonical mechanisms of action

Mitchell Goldfarb  1   2
Affiliations
Review

Fibroblast growth factor homologous factors: canonical and non-canonical mechanisms of action

Mitchell Goldfarb. J Physiol. 2024 Sep.

Abstract

Since their discovery nearly 30 years ago, fibroblast growth factor homologous factors (FHFs) are now known to control the functionality of excitable tissues through a range of mechanisms. Nervous and cardiac system dysfunctions are caused by loss- or gain-of-function mutations in FHF genes. The best understood 'canonical' targets for FHF action are voltage-gated sodium channels, and recent studies have expanded the repertoire of ways that FHFs modulate sodium channel gating. Additional 'non-canonical' functions of FHFs in excitable and non-excitable cells, including cancer cells, have been reported over the past dozen years. This review summarizes and evaluates reported canonical and non-canonical FHF functions.

Keywords: FGFR; FHF; cancer cells; cardiac electrophysiology; iFGF; neuronal excitability; sodium channel; synaptic transmission.

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