Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 1;14(4):192-200.
doi: 10.4103/mgr.MEDGASRES-D-23-00006. Epub 2024 Mar 28.

Mechanisms of nitric oxide in spinal cord injury

Jiahui Hao  1 , Yang Ye, Guoguo Zhang, Haitao Shen, Jinquan Li, Gang Chen
Affiliations
Review

Mechanisms of nitric oxide in spinal cord injury

Jiahui Hao et al. Med Gas Res. .

Abstract

Spinal cord injury (SCI) is a primary lesion of the spinal cord that results from external forces or diseases, accompanied by a cascade of secondary events. Nitric oxide, an endogenous gas that functions as a signaling molecule in the human body, plays a crucial role in vasodilation of smooth muscles, regulation of blood flow and pressure, and inflammatory response. This article provides a comprehensive overview of the involvement of nitric oxide in SCI and highlights recent advances in basic research on pharmacological agents that inhibit nitric oxide elevation after SCI, offering valuable insights for future therapeutic interventions targeting SCI.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

The authors declare no conflicts of interest.

Editor note: GC is an Editorial Board member of Medical Gas Research. He is blinded from reviewing or making decisions on the manuscript. The article was subject to the journal's standard procedures, with peer review handled independently of this Editorial Board member and his research group.

Figures

Figure 1
Figure 1
NO is an endogenous gas that acts as a signal molecule in the human body. Note: NO is produced by L-arginine and oxygen under the action of NOS. Created with BioRender.com. cGMP: Cyclic guanosine 3′,5′-monophosphate; NO: nitric oxide; NOS: nitric oxide synthase; SCI: spinal cord injury.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Eli I, Lerner DP, Ghogawala Z. Acute traumatic spinal cord injury. Neurol Clin. 2021;39:471–488. - PubMed
    1. Karsy M, Hawryluk G. Modern medical management of spinal cord injury. Curr Neurol Neurosci Rep. 2019;19:65. - PubMed
    1. Anjum A, Yazid MD, Fauzi Daud M, et al. Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci. 2020;21:7533. - PMC - PubMed
    1. Melis MR, Argiolas A. Erectile function and sexual behavior: a review of the role of nitric oxide in the central nervous system. Biomolecules. 2021;11:1866. - PMC - PubMed
    1. O'Gallagher K, Puledda F, O'Daly O, et al. Neuronal nitric oxide synthase regulates regional brain perfusion in healthy humans. Cardiovasc Res. 2022;118:1321–1329. - PMC - PubMed