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Review
. 2024 Jun 27;14(7):361.
doi: 10.3390/metabo14070361.

Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes

Renata Saucedo  1 , Aldo Ferreira-Hermosillo  1 , Magalhi Robledo-Clemente  2 , Mary Flor Díaz-Velázquez  2 , Jorge Valencia-Ortega  3
Affiliations
Review

Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes

Renata Saucedo et al. Metabolites. .

Abstract

Offspring exposed to gestational diabetes mellitus (GDM) exhibit greater adiposity at birth. This early-life phenotype may increase offspring risk of developing obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease later in life. Infants born to women with GDM have a dysregulation of several hormones, cytokines, and growth factors related to fetal fat mass growth. One of the molecular mechanisms of GDM influencing these factors is epigenetic alterations, such as DNA methylation (DNAm). This review will examine the role of DNAm as a potential biomarker for monitoring fetal growth during pregnancy in women with GDM. This information is relevant since it may provide useful new biomarkers for the diagnosis, prognosis, and treatment of fetal growth and its later-life health consequences.

Keywords: DNA methylation; birth weight; epigenetics; gestational diabetes; macrosomia.

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Conflict of interest statement

The authors declare no conflicts of interest.

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