Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy?
- PMID: 39053604
- PMCID: PMC11381887
- DOI: 10.1016/j.advnut.2024.100277
Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy?
Abstract
The escalating threat of antimicrobial resistance underscores the imperative for innovative therapeutic strategies. Host defense peptides (HDPs), integral components of innate immunity, exhibit profound antimicrobial and immunomodulatory properties. Various dietary compounds, such as short-chain fatty acids, vitamins, minerals, sugars, amino acids, phytochemicals, bile acids, probiotics, and prebiotics have been identified to enhance the synthesis of endogenous HDPs without provoking inflammatory response or compromising barrier integrity. Additionally, different classes of these compounds synergize in augmenting HDP synthesis and disease resistance. Moreover, dietary supplementation of several HDP-inducing compounds or their combinations have demonstrated robust protection in rodents, rabbits, pigs, cattle, and chickens from experimental infections. However, the efficacy of these compounds in inducing HDP synthesis varies considerably among distinct compounds. Additionally, the regulation of HDP genes occurs in a gene-specific, cell type-specific, and species-specific manner. In this comprehensive review, we systematically summarized the modulation of HDP synthesis and the mechanism of action attributed to each major class of dietary compounds, including their synergistic combinations, across a spectrum of animal species including humans. We argue that the ability to enhance innate immunity and barrier function without triggering inflammation or microbial resistance positions the nutritional modulation of endogenous HDP synthesis as a promising host-directed approach for mitigating infectious diseases and antimicrobial resistance. These HDP-inducing compounds, particularly in combinations, harbor substantial clinical potential for further exploration in antimicrobial therapies for both human and other animals.
Keywords: antimicrobial peptides; antimicrobial resistance; host defense peptides; host-directed antimicrobial therapy; nutritional regulation.
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Figures
Similar articles
-
Transcriptional Regulation of Antimicrobial Host Defense Peptides.Curr Protein Pept Sci. 2015;16(7):672-9. doi: 10.2174/1389203716666150630133432. Curr Protein Pept Sci. 2015. PMID: 26122785 Review.
-
High Throughput Screening for Natural Host Defense Peptide-Inducing Compounds as Novel Alternatives to Antibiotics.Front Cell Infect Microbiol. 2018 Jun 11;8:191. doi: 10.3389/fcimb.2018.00191. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 29942796 Free PMC article.
-
Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics.Anim Nutr. 2018 Jun;4(2):160-169. doi: 10.1016/j.aninu.2018.01.003. Epub 2018 Jan 31. Anim Nutr. 2018. PMID: 30140755 Free PMC article. Review.
-
Regulation of Host Defense Peptide Synthesis by Polyphenols.Antibiotics (Basel). 2023 Mar 28;12(4):660. doi: 10.3390/antibiotics12040660. Antibiotics (Basel). 2023. PMID: 37107022 Free PMC article. Review.
-
Butyrate and Forskolin Augment Host Defense, Barrier Function, and Disease Resistance Without Eliciting Inflammation.Front Nutr. 2021 Oct 27;8:778424. doi: 10.3389/fnut.2021.778424. eCollection 2021. Front Nutr. 2021. PMID: 34778349 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources